ArticleBiomedicines2021
Differential Modulation of Dorsal Horn Neurons by Various Spinal Cord Stimulation Strategies.
Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Spinal Cord Stimulation for Painful Diabetic Neuropathy: A Systematic Review and Meta-Analysis of High- and Low-Frequency Modalities.Pain research & management · 2026Pooled it
- [New paradigms in spinal cord stimulation (SCS): technology and clinical evidence].Schmerz (Berlin, Germany) · 2026Review
- Electromagnetic neuromodulation for chronic pain: historical context, contemporary modalities, and evidence gaps.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Response of dorsal horn neurons in mice to high-frequency (kHz) biphasic stimulation is not sensitive to local temperature rise.Physiological reports · 2025Article
- Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics.Communications biology · 2025Article
- Extreme pulse dosing of 10 kHz spinal cord stimulation: how low can you go?Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Mechanisms and clinical progress of spinal cord stimulation in refractory chronic pain: an overview.Frontiers in neurology · 2025Review
- Radiofrequency stimulation of the dorsal root ganglion as a diagnostic tool for radicular pain syndromes: six representative cases.Journal of anesthesia, analgesia and critical care · 2024Article
- Frequency-Dependent Neural Modulation of Dorsal Horn Neurons by Kilohertz Spinal Cord Stimulation in Rats.Biomedicines · 2024Article
- Spinal Cord Stimulation for Painful Diabetic Neuropathy.Journal of diabetes science and technology · 2024Review
- Model-based analysis of subthreshold mechanisms of spinal cord stimulation for pain.Journal of neural engineering · 2023Article
- An optimization framework for targeted spinal cord stimulation.Journal of neural engineering · 2023Article
- Stimulating Results Signal a New Treatment Option for People Living With Painful Diabetic Neuropathy.Journal of diabetes science and technology · 2023Review
- Advances in Spinal Cord Stimulation.Bioengineering (Basel, Switzerland) · 2023Review
- Review
- A Real-World Analysis of High-Frequency 10 kHz Spinal Cord Stimulation for the Treatment of Painful Diabetic Peripheral Neuropathy.Journal of diabetes science and technology · 2022Article
- Concept of the Number Needed to Treat for the Analysis of Pain Relief Outcomes in Patients Treated with Spinal Cord Stimulation.Biomedicines · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New strategies for spinal cord stimulation (SCS) for chronic pain have emerged in recent years, which may work better via different analgesic mechanisms than traditional low-frequency (e.g., 50 Hz) paresthesia-based SCS. To determine if 10 kHz and burst SCS waveforms might have a similar mechanistic basis, we examined whether these SCS strategies at intensities ostensibly below sensory thresholds would modulate spinal dorsal horn (DH) neuronal function in a neuron type-dependent manner. By using an in vivo electrophysiological approach in rodents, we found that low-intensity 10 kHz SCS, but not burst SCS, selectively activates inhibitory interneurons in the spinal DH. This study suggests that low-intensity 10 kHz SCS may inhibit pain-sensory processing in the spinal DH by activating inhibitory interneurons without activating DC fibers, resulting in paresthesia-free pain relief, whereas burst SCS likely operates via other mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.