Evidence map›Paper›PMID 34070079›Full record

ArticleBrain sciences2021

Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats.

Katharina Braun, Anja Mannewitz, Joerg Bock, Silke Kreitz, Andreas Hess, Henning Scheich, Jürgen Goldschmidt

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Katharina BraunDepartment of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
Anja MannewitzDepartment of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
Joerg BockCenter for Behavioral Brain Sciences, 39106 Magdeburg, Germany.
Silke KreitzInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University, 91054 Erlangen, Germany.
Andreas HessInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University, 91054 Erlangen, Germany.
Henning ScheichCenter for Behavioral Brain Sciences, 39106 Magdeburg, Germany.
Jürgen GoldschmidtCenter for Behavioral Brain Sciences, 39106 Magdeburg, Germany.
Otto-von-Guericke University Magdeburg · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DECenter for Behavioral Brain Sciences · DELeibniz Institute for Neurobiology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Active avoidance learning is a complex form of aversive feedback learning that in humans and other animals is essential for actively coping with unpleasant, aversive, or dangerous situations. Since the functional circuits involved in two-way avoidance (TWA) learning have not yet been entirely identified, the aim of this study was to obtain an overall picture of the brain circuits that are involved in active avoidance learning. In order to obtain a longitudinal assessment of activation patterns in the brain of freely behaving rats during different stages of learning, we applied single-photon emission computed tomography (SPECT). We were able to identify distinct prefrontal cortical, sensory, and limbic circuits that were specifically recruited during the acquisition and retrieval phases of the two-way avoidance learning task.

Indexed as

acquisitionavoidance learningfunctional imaginglimbic systemmemory retrievalprefrontal cortex

Identifiers

PMID34070079
PMCPMC8158148
OpenAlexW3160247512

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.