Evidence map›Paper›PMID 34070078›Full record

ArticleCancers2021

Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response.

Chun-Shan Liu, Reka Toth, Ali Bakr, Ashish Goyal, Md Saiful Islam, Kersten Breuer, Anand Mayakonda, Yu-Yu Lin, Peter Stepper, Tomasz P Jurkowski and 8 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Chronic radiation-induced dermatitis: what is new in 2024? A narrative review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Chun-Shan LiuDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0003-0887-0484
Reka TothDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-6096-1052
Ali BakrDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-6111-0591
Ashish GoyalDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Md Saiful IslamDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Kersten BreuerDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Anand MayakondaDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Yu-Yu LinDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Peter StepperInstitute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569 Stuttgart, Germany.ORCID 0000-0003-1785-2405
Tomasz P JurkowskiInstitute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569 Stuttgart, Germany.
Marlon R VeldwijkDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Elena SperkDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-8771-8124
Carsten HerskindDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Pavlo LutsikDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Dieter WeichenhanDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-7915-412X
Christoph PlassDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Peter SchmezerDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Odilia PopandaDivision of Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Funding

Deutsche Forschungsgemeinschaft 429192355Deutsche Krebshilfe 70112734
6 · The paper itself

Abstract

Radiotherapy, a common component in cancer treatment, can induce adverse effects including fibrosis in co-irradiated tissues. We previously showed that differential DNA methylation at an enhancer of diacylglycerol kinase alpha (

Indexed as

bromodomain inhibitorsDNA methylationEZH2 inhibitorsradiotherapy-induced fibrosis

Identifiers

PMID34070078
PMCPMC8158145

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.