ArticleNanomaterials (Basel, Switzerland)2021
Cytokine-Mediated Inflammation in the Oral Cavity and Its Effect on Lipid Nanocarriers.
Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Modular design for drug delivery across hierarchical gastrointestinal barriers: From materials to systems.Materials today. Bio · 2026Review
- Reactive oxygen species-sensitive release of cephalexin from hyaluronic acid-g-cephalexin dimer copolymer for treatment of inflammation and infection of oral soft tissue cells.Scientific reports · 2025Article
- Boosting buccal drug absorption: Mechanistic insights into bilosome-mediated delivery.International journal of pharmaceutics: X · 2025Article
- On the Structure, Stability, and Cell Uptake of Nanostructured Lipid Carriers for Drug Delivery.Molecular pharmaceutics · 2024Article
- Archaeosomes for Oral Drug Delivery: From Continuous Microfluidics Production to Powdered Formulations.Pharmaceutics · 2024Article
- Investigation of Hydrocolloid Plant Polysaccharides as Potential Candidates to Mimic the Functions of MUC5B in Saliva.Pharmaceutics · 2024Article
- Transport of Non-Steroidal Anti-Inflammatory Drugs across an Oral Mucosa Epithelium In Vitro Model.Pharmaceutics · 2024Article
- Green Synthesis of Gold Nanoparticles with Curcumin or Açai in the Tissue Repair of Palatal Wounds.Antioxidants (Basel, Switzerland) · 2023Article
- Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells.Frontiers in molecular biosciences · 2022Article
- Orofacial clefts lead to increased pro-inflammatory cytokine levels on neonatal oral mucosa.Frontiers in immunology · 2022Article
- Estimation of Serum, Salivary, and Gingival Crevicular Uric Acid of Individuals With and Without Periodontal Disease: A Systematic Review and Meta-analysis.Journal of International Society of Preventive & Community DentistryReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topical drug administration to the oral mucosa proves to be a promising treatment alternative for inflammatory diseases. However, disease-related changes in the cell barrier must be considered when developing such delivery systems. This study aimed at investigating the changes in the lining mucosa caused by inflammation and evaluating the consequences on drug delivery systems such as nanostructured lipid carriers (NLC). For this, TR146 cells were treated with inflammatory cytokines and bacterial components. Cell viability and integrity, reactive oxygen species (ROS), and interleukin (IL)-8 release were used as endpoints to assess inflammation. Translocation of phosphatidylserine, cytoskeletal arrangement, opening of desmosomes, and cell proliferation were examined. Transport studies with NLC were performed considering active and passive pathways. The results showed that IL-1ß and tumor necrosis factor α induced inflammation by increasing IL-8 and ROS production (22-fold and 2-fold). Morphologically, loss of cell-cell connections and formation of stress fibers and hyperplasia were observed. The charge of the cell membrane shifted from neutral to negative, which increased the absorption of NLC due to the repulsive interactions between the hydrophobic negative particles and the cell membrane on the one hand, and interactions with lipophilic membrane proteins such as caveolin on the other.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.