ReviewHealthcare (Basel, Switzerland)2021
Phthalates and Their Impacts on Human Health.
Review in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
178 citing papers in PubMed, 6 syntheses or guidelines pooled it, 551 citations in OpenAlex.
- Phthalates as the silent saboteurs of male fertility via changes in semen quality: a systematic review.Reproductive biology and endocrinology : RB&E · 2026Pooled it
- A Systematic Literature Review of Reproductive Toxicological Studies on Phthalates.International journal of molecular sciences · 2025Pooled it
- Filling gaps in population estimates of phthalate exposure globally: A systematic review and meta-analysis of international biomonitoring data.International journal of hygiene and environmental health · 2025Pooled it
- The impact of exposure to phthalates in thyroid function of children and adolescents: a systematic review.European journal of pediatrics · 2024Pooled it
- Phthalate Exposure and Neurotoxicity in Children: A Systematic Review and Meta-analysis.International journal of public health · 2024Pooled it
- Phthalates and bone mineral density: a systematic review.Environmental health : a global access science source · 2022Pooled it
- Phthalate Metabolite, Mono(2-Ethyl-5-Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine-Fibroid-Associated Phenotypes in Myometrial Stem Cell-Derived 3D Organoids.Environmental toxicology · 2026Article
- Article
- Prenatal and early life phthalate exposure and early life stress: no interactions with adolescent internalizing symptoms.Environment international · 2026Article
- Long-Term Industrial Emissions Exposure and Cognitive Impairment in Older U.S. Adults: A Longitudinal Cohort Study.Health science reports · 2026Article
- Effects of dibutyl phthalate on early implantation events with human endometrial cells and trophoblast spheroid model.Clinical and experimental reproductive medicine · 2026Article
- Neuroendocrine Disruption of Reproduction by Bisphenols and Phthalates: From Molecular Mechanisms to Reproductive Outcomes.International journal of molecular sciences · 2026Review
- Critical Evaluation of Key Elements in Manufacturing Procedures and Testing Methodologies for Ocular Anti-Infective Thin Film Inserts.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Metabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalate.Molecular metabolism · 2026Article
- Persistence of Polycyclic Aromatic Hydrocarbons and Microplastics: A Serious Alarm to Human Health and Ecosystems.Chemical record (New York, N.Y.) · 2026Review
- Exposure to bisphenols and phthalates and arterial stiffness in women of reproductive age: a New York City cohort analysis.Environment international · 2026Article
- Green and Rapid Determination of Phthalates in Mineral Water From Virgin and Recycled PET Bottles.Journal of mass spectrometry : JMS · 2026Article
- Review
- Review
- The Thyroid Under Pressure: Heavy Metals, Endocrine Disruptors and Translational Insights into Carcinogenesis and Thyroid Dysfunctions.International journal of molecular sciences · 2026Review
118 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Phthalates are a series of widely used chemicals that demonstrate to be endocrine disruptors and are detrimental to human health. Phthalates can be found in most products that have contact with plastics during producing, packaging, or delivering. Despite the short half-lives in tissues, chronic exposure to phthalates will adversely influence the endocrine system and functioning of multiple organs, which has negative long-term impacts on the success of pregnancy, child growth and development, and reproductive systems in both young children and adolescents. Several countries have established restrictions and regulations on some types of phthalates; however, we think that more countries should establish constraints or substitute measures for phthalates to reduce health risks. This article aims to summarize the adverse impacts of phthalates on human health, analyze the toxicity mechanism, assess the risks, and finally provide feasible strategies to reduce exposure of the public to phthalates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.