ArticleJournal of functional biomaterials2021
TiAl6V4 Alloy Surface Modifications and Their Impact on Biofilm Development of
Article in Journal of functional biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Biofilm Formation Patterns ofAntibiotics (Basel, Switzerland) · 2026Article
- Effect of Rare-Earth Element Microdoping on Ti-6Al-7Nb Alloys for Biomedical Applications: Materials Characterization and In Vivo Biocompatibility Tests.Materials (Basel, Switzerland) · 2026Article
- Laser-Driven Surface Alloying of Ti6Al4V: Coupled Microstructural Evolution, Phase Behavior, and Mechanical Performance.Materials (Basel, Switzerland) · 2025Article
- Classical and Modern Models for Biofilm Studies: A Comprehensive Review.Antibiotics (Basel, Switzerland) · 2024Review
- ROLE OF INCISIONAL VACUUM THERAPY IN ENDOPROSTHETIC BONE RECONSTRUCTION SURGERY.Acta ortopedica brasileira · 2023Article
- Effect of Treated Time of Hydrothermal Etching Process on Oxide Layer Formation and Its Antibacterial Properties.Biomimetics (Basel, Switzerland) · 2022Article
- Effect of Cobalt-Chromium-Molybdenum Implant Surface Modifications on Biofilm Development ofFrontiers in cellular and infection microbiology · 2022Article
- Wear Resistance of Ti-6Al-4V Alloy Ball Heads for Use in Implants.Journal of functional biomaterials · 2021Article
- Infections @ Trauma/Orthopedic Implants: Recent Advances on Materials, Methods, and Microbes-A Mini-Review.Materials (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
One of the most serious complications following joint replacement surgeries are periprosthetic infections (PIs) arising from the adhesion of bacteria to the artificial joint. Various types of titanium-aluminum-vanadium (TiAl6V4) alloy surface modifications (coatings with silver (Ag), titanium nitride (TiN), pure titanium (cpTi), combinations of cpTi and hydroxyapatite (HA), combinations of cpTi and tricalcium phosphate (TCP), and a rough-blasted surface of TiAl6V4) have been investigated to assess their effects on biofilm development. Biofilms were grown, collected, and analyzed after 48 h to measure their protein and glucose content and the cell viability. Biofilm-associated genes were also monitored after 48 h of development. There was a distinct difference in the development of staphylococcal biofilms on the surfaces of the different types of alloy. According to the findings of this study, the base alloy TiAl6V4 and the TiN-coated surface are the most promising materials for biofilm reduction. Rough surfaces are most favorable when it comes to bacterial infections because they allow an easy attachment of pathogenic organisms. Of all rough surfaces tested, rough-blasted TiAl6V4 was the most favorable as an implantation material; all the other rough surfaces showed more distinct signs of inducing the development of biofilms which displayed higher protein and polysaccharide contents. These results are supported by RT-qPCR measurements of biofilm associated genes for
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