Evidence map›Paper›PMID 34069733›Full record

ReviewPharmaceutics2021

A Review of Mathematics Determining Solute Uptake at the Blood-Brain Barrier in Normal and Pathological Conditions.

Samuel A Sprowls, Pushkar Saralkar, Tasneem Arsiwala, Christopher E Adkins, Kathryn E Blethen, Vincenzo J Pizzuti, Neal Shah, Ross Fladeland, Paul R Lockman

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Samuel A SprowlsBasic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0003-1995-0586
Pushkar SaralkarBasic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.
Tasneem ArsiwalaBasic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0002-5799-0514
Christopher E AdkinsSchool of Pharmacy, South University, Savannah, GA 31406, USA.
Kathryn E BlethenBasic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0003-4602-9514
Vincenzo J PizzutiBasic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0002-1708-3776
Neal ShahHealth Sciences Center, West Virginia University, Morgantown, WV 26506, USA.
Ross FladelandBasic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.
Paul R LockmanBasic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0002-6995-9944
West Virginia University · USSouth University · US

Funding

WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Dominique Bollino · 2018 to 2026
$22.4M
Disruptive methods for increased chemotherapy distribution into preclinical brain metastases of breast cancer leading to improved tumor kill and prolonged survival.F99CA253768 · NCI · WEST VIRGINIA UNIVERSITY · PI SPROWLS, SAMUEL ADAM TYLER · 2020 to 2021
$47k
NCI NIH HHS 1F99CA253768-01NCI NIH HHS F99 CA253768NIGMS NIH HHS 5P20GM121322-03NIGMS NIH HHS 5P20GM121322-03S1
6 · The paper itself

Abstract

The blood-brain barrier (BBB) limits movement of solutes from the lumen of the brain microvascular capillary system into the parenchyma. The unidirectional transfer constant,

Indexed as

blood–brain barrierbrainmagnetic-resonance imagingpharmacokineticspreclinical models

Identifiers

PMID34069733
PMCPMC8160855
OpenAlexW3160735700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.