Evidence map›Paper›PMID 34069653›Full record

ArticleMolecules (Basel, Switzerland)2021

New Cardenolides from Biotransformation of Gitoxigenin by the Endophytic Fungus

Erdal Bedir, Çiğdem Karakoyun, Gamze Doğan, Gülten Kuru, Melis Küçüksolak, Hasan Yusufoğlu

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erdal BedirDepartment of Bioengineering, Faculty of Engineering, İzmir Institute of Technology, 35430 Urla-İzmir, Turkey.ORCID 0000-0003-1262-063X
Çiğdem KarakoyunDepartment of Pharmacognosy, Faculty of Pharmacy, Ege University, 35100 Bornova-İzmir, Turkey.ORCID 0000-0003-1150-7061
Gamze DoğanDepartment of Bioengineering, Faculty of Engineering, İzmir Institute of Technology, 35430 Urla-İzmir, Turkey.ORCID 0000-0002-4268-8419
Gülten KuruDepartment of Bioengineering, Faculty of Engineering, İzmir Institute of Technology, 35430 Urla-İzmir, Turkey.ORCID 0000-0001-5286-4933
Melis KüçüksolakDepartment of Bioengineering, Faculty of Engineering, İzmir Institute of Technology, 35430 Urla-İzmir, Turkey.ORCID 0000-0003-1619-4850
Hasan YusufoğluDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.

Funding

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu 119Z152
6 · The paper itself

Abstract

Microbial biotransformation is an important tool in drug discovery and for metabolism studies. To expand our bioactive natural product library via modification and to identify possible mammalian metabolites, a cytotoxic cardenolide (gitoxigenin) was biotransformed using the endophytic fungus

Indexed as

AlternariaAntineoplastic Agents, PhytogenicBiotransformationCardenolidesCell Line, TumorDrug Screening Assays, AntitumorHEK293 CellsHumansSpectrum AnalysisAntineoplastic Agents, PhytogenicCardenolidesgitoxigeninAlternaria eureka 1E1BL1biotransformationcardenolidescytotoxicityendophytic fungusgitoxigeninNerium oleander L.oleandrin

Identifiers

PMID34069653
PMCPMC8161373

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.