Evidence map›Paper›PMID 34069639›Full record

ArticleMolecules (Basel, Switzerland)2021

Design, Synthesis, and Evaluation of Dihydropyranopyrazole Derivatives as Novel PDE2 Inhibitors for the Treatment of Alzheimer's Disease.

Yan Zhou, Jinjian Li, Han Yuan, Rui Su, Yue Huang, Yiyou Huang, Zhe Li, Yinuo Wu, Haibin Luo, Chen Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Magnetic FeRSC advances · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yan ZhouSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.ORCID 0000-0001-7163-9053
Jinjian LiSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Han YuanSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Rui SuSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Yue HuangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Yiyou HuangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Zhe LiSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Yinuo WuSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Haibin LuoSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Chen ZhangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Ling HuangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Sun Yat-sen University · CN

Funding

Guangzhou Pearl River New Star Fund Science and Technology Planning Project 201806010190Natural Science Foundation of China 21772241Natural Science Foundation of China 82003652
6 · The paper itself

Abstract

Phosphodiesterase 2 (PDE2) has been regarded as a novel target for the treatment of Alzheimer's disease (AD). In this study, we obtained (

Indexed as

Alzheimer DiseaseDrug DesignDrug Evaluation, PreclinicalHumansInhibitory Concentration 50Molecular Docking SimulationPhosphodiesterase InhibitorsPyrazolesSpectrum AnalysisPhosphodiesterase InhibitorsPyrazolesAlzheimer’s diseasedihydropyranopyrazole derivativesPDE2 inhibitors

Identifiers

PMID34069639
PMCPMC8160813
OpenAlexW3165252072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.