Evidence map›Paper›PMID 34069569›Full record

ArticleCancers2021

Clearance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection or Liver Transplantation.

Víctor Amado, Sandra González-Rubio, Javier Zamora, Rafael Alejandre, María Lola Espejo-Cruz, Clara Linares, Marina Sánchez-Frías, Gema García-Jurado, José Luis Montero, Rubén Ciria and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Víctor AmadoDepartment of Hepatology and Liver Transplantation, Reina Sofía University Hospital, 14004 Córdoba, Spain.ORCID 0000-0003-2816-9038
Sandra González-RubioMaimónides Institute of Biomedical Research (IMIBIC), University of Córdoba, 14004 Córdoba, Spain.
Javier ZamoraDepartment of Hepatology and Liver Transplantation, Reina Sofía University Hospital, 14004 Córdoba, Spain.
Rafael AlejandreDepartment of Hepatology and Liver Transplantation, Reina Sofía University Hospital, 14004 Córdoba, Spain.
María Lola Espejo-CruzMaimónides Institute of Biomedical Research (IMIBIC), University of Córdoba, 14004 Córdoba, Spain.
Clara LinaresMaimónides Institute of Biomedical Research (IMIBIC), University of Córdoba, 14004 Córdoba, Spain.
Marina Sánchez-FríasPathology Department, Reina Sofía University Hospital, 14004 Córdoba, Spain.
Gema García-JuradoMaimónides Institute of Biomedical Research (IMIBIC), University of Córdoba, 14004 Córdoba, Spain.
José Luis MonteroDepartment of Hepatology and Liver Transplantation, Reina Sofía University Hospital, 14004 Córdoba, Spain.
Rubén CiriaMaimónides Institute of Biomedical Research (IMIBIC), University of Córdoba, 14004 Córdoba, Spain.
Manuel Rodríguez-PerálvarezDepartment of Hepatology and Liver Transplantation, Reina Sofía University Hospital, 14004 Córdoba, Spain.ORCID 0000-0002-1795-2919
Gustavo FerrínMaimónides Institute of Biomedical Research (IMIBIC), University of Córdoba, 14004 Córdoba, Spain.
Manuel De la MataDepartment of Hepatology and Liver Transplantation, Reina Sofía University Hospital, 14004 Córdoba, Spain.

Funding

European Regional Development Fund PI14/01469 and PI18/01736Instituto de Salud Carlos III PI14/01469 and PI18/01736
6 · The paper itself

Abstract

backgroundIn patients with hepatocellular carcinoma (HCC), a complete clearance of circulating tumor cells (CTCs) early after liver transplantation (LT) or surgical resection (LR) could prevent tumor recurrence.

methodsprospective pilot study including patients with HCC who underwent LR or LT from September 2017 to May 2020. Enumeration of CTCs was performed in peripheral blood samples (7 mL) using the Isoflux

results41 HCC patients were included (mean age 58.7 ± 6.3; 82.9% male). LR was performed in 10 patients (24.4%) and 31 patients (75.6%) underwent LT. The main etiology of liver disease was chronic hepatitis C (31.7%). Patients undergoing LR and LT were similar in terms of preoperative CTC count (

conclusionIncomplete clearance of CTCs after surgery could be a surrogate marker of HCC aggressiveness.

Indexed as

circulating tumor cellhepatocellular carcinomaliquid biopsyliver cancerliver transplantation

Identifiers

PMID34069569
PMCPMC8160727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.