Evidence map›Paper›PMID 34069514›Full record

ArticlePathogens (Basel, Switzerland)2021

Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation.

Sarah-Kim Friedrich, Rosa Schmitz, Michael Bergerhausen, Judith Lang, Vikas Duhan, Cornelia Hardt, Matthias Tenbusch, Marco Prinz, Kenichi Asano, Hilal Bhat and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Sarah-Kim FriedrichInstitute of Immunology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.
Rosa SchmitzInstitute of Immunology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.
Michael BergerhausenInstitute of Immunology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.
Judith LangInstitute of Immunology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.ORCID 0000-0001-5352-106X
Vikas DuhanInstitute of Immunology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.ORCID 0000-0002-6337-8225
Cornelia HardtInstitute of Immunology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.
Matthias TenbuschInstitute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.ORCID 0000-0003-3951-9056
Marco PrinzInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Kenichi AsanoLaboratory of Immune Regulation, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan.
Hilal BhatInstitute of Immunology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.
Thamer A HamdanInstitute of Immunology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.
Philipp Alexander LangInstitute of Molecular Medicine II, University of Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Karl Sebastian LangInstitute of Immunology, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.
University of Duisburg-Essen · DEAmerican University of Madaba · JOFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHeinrich Heine University Düsseldorf · DETokyo University of Pharmacy and Life Sciences · JPUniversity Hospital Cologne · DEUniversity of Freiburg · DE

Funding

German Research Council with Research training group RTG1949 and RTG2098, collaborative research center CRC974 LA1419/7-1 and LA1419/10-1
6 · The paper itself

Abstract

The replication of viruses in secondary lymphoid organs guarantees sufficient amounts of pattern-recognition receptor ligands and antigens to activate the innate and adaptive immune system. Viruses with broad cell tropism usually replicate in lymphoid organs; however, whether a virus with a narrow tropism relies on replication in the secondary lymphoid organs to activate the immune system remains not well studied. In this study, we used the artificial intravenous route of infection to determine whether Influenza A virus (IAV) replication can occur in secondary lymphatic organs (SLO) and whether such replication correlates with innate immune activation. Indeed, we found that IAV replicates in secondary lymphatic tissue. IAV replication was dependent on the expression of Sialic acid residues in antigen-presenting cells and on the expression of the interferon-inhibitor UBP43 (

Indexed as

enforced viral replicationInfluenza virusinnate immune activation

Identifiers

PMID34069514
PMCPMC8160763
OpenAlexW3160365931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.