Evidence map›Paper›PMID 34069476›Full record

ArticleCells2021

Transcription Factor β-Catenin Plays a Key Role in Fluid Flow Shear Stress-Mediated Glomerular Injury in Solitary Kidney.

Tarak Srivastava, Daniel P Heruth, R Scott Duncan, Mohammad H Rezaiekhaligh, Robert E Garola, Lakshmi Priya, Jianping Zhou, Varun C Boinpelly, Jan Novak, Mohammed Farhan Ali and 8 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Shear Forces and the Vulnerability of the Podocyte.Journal of the American Society of Nephrology : JASN · 2025
    Article
  3. Article
  4. Prostanoid receptors in hyperfiltration-mediated glomerular injury: Novel agonists and antagonists reveal opposing roles for EP2 and EP4 receptors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

Tarak SrivastavaSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO 64108, USA.
Daniel P HeruthChildren's Mercy Research Institute, Children's Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO 64108, USA.ORCID 0000-0003-3170-2585
R Scott DuncanSchool of Biological Sciences, University of Missouri at Kansas City, Kansas City, MO 64108, USA.
Mohammad H RezaiekhalighSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO 64108, USA.
Robert E GarolaDepartment of Pathology and Laboratory Medicine, Children's Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO 64108, USA.
Lakshmi PriyaSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO 64108, USA.
Jianping ZhouMidwest Veterans' Biomedical Research Foundation (MVBRF), Kansas City, MO 64128, USA.
Varun C BoinpellyMidwest Veterans' Biomedical Research Foundation (MVBRF), Kansas City, MO 64128, USA.
Jan NovakDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35487, USA.
Mohammed Farhan AliSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO 64108, USA.
Trupti JoshiDepartment of Health Management and Informatics, University of Missouri, Columbia, MO 65211, USA.
Uri S AlonSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO 64108, USA.
Yuexu JiangDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.
Ellen T McCarthyDepartment of Internal Medicine, The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Virginia J SavinKansas City VA Medical Center, Kansas City, MO 64128, USA.
Ram SharmaKansas City VA Medical Center, Kansas City, MO 64128, USA.
Mark L JohnsonDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri at Kansas City, Kansas City, MO 64108, USA.
Mukut SharmaMidwest Veterans' Biomedical Research Foundation (MVBRF), Kansas City, MO 64128, USA.
Children's Mercy Hospital · USBiomedical Research Foundation · USKansas City VA Medical Center · USUniversity of Missouri–Kansas City · USUniversity of Alabama at Birmingham · USUniversity of Kansas Medical Center · USUniversity of Missouri · USUniversity of Missouri Health System · US

Funding

Targeting PGE2 Receptors to attenuate shear stress-induced glomerular injuryR01DK107490 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI SRIVASTAVA, TARAK · 2016 to 2020
$2.0M
NIDDK NIH HHS R01 DK107490NIDDK NIH HHS R01DK107490U.S. Department of Veterans Affairs VA BX001037
6 · The paper itself

Abstract

Increased fluid flow shear stress (FFSS) in solitary kidney alters podocyte function

Indexed as

Glomerular Filtration RateMechanotransduction, CellularAnimalsbeta CateninCell LineDatabases, GeneticDisease Models, AnimalGenes, fosLac OperonLymphoid Enhancer-Binding Factor 1Mice, TransgenicPodocytesPromoter Regions, GeneticSolitary KidneyStress, MechanicalTranscription Factor 3beta CateninCTNNB1 protein, mouseLymphoid Enhancer-Binding Factor 1Transcription Factor 3fluid flow shear stressglomerular filtration barrierglomerular hemodynamicshyperfiltrationpodocytes

Identifiers

PMID34069476
PMCPMC8159099
OpenAlexW3161514135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.