Evidence map›Paper›PMID 34069460›Full record

ArticlePathogens (Basel, Switzerland)2021

Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate.

Raya Soltane, Amani Chrouda, Ahmed Mostafa, Ahmed A Al-Karmalawy, Karim Chouaïb, Abdelwaheb Dhahri, Rami Adel Pashameah, Ahlam Alasiri, Omnia Kutkat, Mahmoud Shehata and 3 more

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Ligand-based design and synthesis ofJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  10. Ligand-based design, synthesis, computational insights, andJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  11. Article
  12. Anticoagulants as Potential SARS-CoV-2 MInternational journal of molecular sciences · 2022
    Article
  13. Recent Advances in Antiviral Activities of Triterpenoids.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Synergistic Antimicrobial Effect ofInfection and drug resistance · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Raya SoltaneDepartment of Basic Sciences, Adham University College, Umm Al-Qura University, Adham 21971, Saudi Arabia.
Amani ChroudaDepartment of Chemistry, College of Science Al-Zulfi, Majmaah University, Al-Majmaah 11952, Saudi Arabia.
Ahmed MostafaCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Dokki, 12622 Cairo, Egypt.ORCID 0000-0002-2878-5714
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, 34518 New Damietta, Egypt.ORCID 0000-0002-8173-6073
Karim ChouaïbLaboratory of Heterocyclic Chemistry, Faculty of Science of Monastir, University of Monastir, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Avenue of Environment, Monastir 5019, Tunisia.
Abdelwaheb DhahriPolymer Materials Engineering, University of Lyon, UMR CNRS 5223, Lyon, 69100 Villeurbanne, France.
Rami Adel PashameahDepartment of Basic Sciences, Adham University College, Umm Al-Qura University, Adham 21971, Saudi Arabia.
Ahlam AlasiriDepartment of Basic Sciences, Adham University College, Umm Al-Qura University, Adham 21971, Saudi Arabia.
Omnia KutkatCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Dokki, 12622 Cairo, Egypt.
Mahmoud ShehataCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Dokki, 12622 Cairo, Egypt.ORCID 0000-0001-7556-9398
Hichem Ben JannetLaboratory of Heterocyclic Chemistry, Faculty of Science of Monastir, University of Monastir, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Avenue of Environment, Monastir 5019, Tunisia.
Jawhar GharbiDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.ORCID 0000-0001-9170-3403
Mohamed A AliCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Dokki, 12622 Cairo, Egypt.ORCID 0000-0002-5615-3212
National Research Centre · EGUmm al-Qura University · SAUniversité Claude Bernard Lyon 1 · FRUniversity of Monastir · TNDamietta University · EGKing Faisal University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In late December 2019, a novel coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), escaped the animal-human interface and emerged as an ongoing global pandemic with severe flu-like illness, commonly known as coronavirus disease 2019 (COVID-19). In this study, a molecular docking study was carried out for seventeen (

Indexed as

maslinic acidMERS-CoVmolecular dockingoleanolic acidSARSARS-CoV-2

Identifiers

PMID34069460
PMCPMC8159111
OpenAlexW3163747902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.