Evidence map›Paper›PMID 34069442›Full record

ArticleNutrients2021

Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor.

Ye Li, Katherine L Cook, Wei Yu, Lu Jin, Kerrie B Bouker, Robert Clarke, Leena Hilakivi-Clarke

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Exploring the Molecular Mechanism of 1,25(OH)Current issues in molecular biology · 2025
    Article
  6. Article
  7. Article
  8. The Role and Clinical Significance of Vitamin D in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025
    Review
  9. Burns & trauma · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Review
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  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ye LiDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.ORCID 0000-0001-7727-0875
Katherine L CookDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.
Wei YuDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.
Lu JinDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.
Kerrie B BoukerDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.
Robert ClarkeDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.ORCID 0000-0002-9278-0854
Leena Hilakivi-ClarkeDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.
Georgetown University · US

Funding

Novel Targets in Endocrine ResponsivenessU54CA149147 · NCI · GEORGETOWN UNIVERSITY · PI MADHAVAN, SUBHA · 2010 to 2014
$6.9M
Transgenerational effects of maternal high fat diet during pregnancy on breast caR01CA164384 · NCI · GEORGETOWN UNIVERSITY · PI HILAKIVI-CLARKE, LEENA A. · 2012 to 2015
$2.0M
National Cancer Center CA51008NCI NIH HHS CA149147NCI NIH HHS CA164384
6 · The paper itself

Abstract

We determined how vitamin D receptor (VDR) is linked to disease outcome in estrogen receptor-positive (ER+) breast cancer patients treated with tamoxifen (TAM). Breast cancer patients (

Indexed as

AnimalsAutophagyBreastBreast NeoplasmsCalcitriolCell Line, TumorDrug Resistance, NeoplasmEndoribonucleasesEstrogen AntagonistsEstrogen Receptor ModulatorsFemaleHumansMCF-7 CellsMiceProtein Serine-Threonine KinasesReceptors, CalcitriolCalcitriolEndoribonucleasesERN1 protein, humanEstrogen AntagonistsEstrogen Receptor ModulatorsProtein Serine-Threonine KinasesReceptors, CalcitriolseocalcitolTamoxifenVDR protein, humanVitamin Dautophagybreast cancerrecurrence-free survivaltamoxifenvitamin D analogsvitamin D receptor

Identifiers

PMID34069442
PMCPMC8159129
OpenAlexW3161038333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.