Evidence map›Paper›PMID 34069424›Full record

ReviewCells2021

Role of Glycans on Key Cell Surface Receptors That Regulate Cell Proliferation and Cell Death.

Yin Gao, Xue Luan, Jacob Melamed, Inka Brockhausen

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 51 citations in OpenAlex.

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  5. Targeting the Dynamics Between TAMs and CAR-T Cells in Solid Tumor Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yin GaoKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.ORCID 0000-0002-0763-0254
Xue LuanKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Jacob MelamedDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L3N6, Canada.ORCID 0000-0002-3703-2925
Inka BrockhausenDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L3N6, Canada.
Jilin University · CNQueen's University · CA

Funding

Department of Science and Technology of Jilin Province 20200801066GHNSERC RGPIN 04782-2016
6 · The paper itself

Abstract

Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated. This review discusses receptor glycosylation and the known roles of glycans on the functions of receptors expressed in diverse cell types. We included growth factor receptors that have an intracellular tyrosine kinase domain, growth factor receptors that have a serine/threonine kinase domain, and cell-death-inducing receptors.

Indexed as

Cell ProliferationProtein Processing, Post-TranslationalAnimalsCell DeathCell MembraneGlycosylationHumansLigandsPolysaccharidesReceptors, Cell SurfaceReceptors, Death DomainSignal TransductionLigandsPolysaccharidesReceptors, Cell SurfaceReceptors, Death DomainN-glycansO-glycansreceptorssignalingTGFRtyrosine kinase

Identifiers

PMID34069424
PMCPMC8159107
OpenAlexW3160590344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.