Evidence map›Paper›PMID 34069423›Full record

ArticleInternational journal of molecular sciences2021

Noscapine Acts as a Protease Inhibitor of In Vitro Elastase-Induced Collagen Deposition in Equine Endometrium.

Ana Amaral, Carina Fernandes, Anna Szóstek-Mioduchowska, Maria Rosa Rebordão, Dariusz Jan Skarzynski, Graça Ferreira-Dias

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ana AmaralCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Departamento de Morfologia e Função, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal.ORCID 0000-0002-0075-262X
Carina FernandesCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Departamento de Morfologia e Função, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal.
Anna Szóstek-MioduchowskaInstitute of Animal Reproduction and Food Research, Polish Academy of Science, 10-748 Olsztyn, Poland.
Maria Rosa RebordãoCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Departamento de Morfologia e Função, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal.ORCID 0000-0002-4389-445X
Dariusz Jan SkarzynskiInstitute of Animal Reproduction and Food Research, Polish Academy of Science, 10-748 Olsztyn, Poland.ORCID 0000-0001-9537-3560
Graça Ferreira-DiasCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Departamento de Morfologia e Função, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal.ORCID 0000-0003-0622-6513
University of Lisbon · PTInLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences · PL

Funding

Fundação para a Ciência e a Tecnologia PTDC/CVT-REP/4202/2014Fundação para a Ciência e a Tecnologia SFRH/BD/101058/2014Fundação para a Ciência e a Tecnologia UIDB/00276/2020Narodowa Agencja Wymiany Akademickiej PPN/BIL/2018/1/00250/U/0001
6 · The paper itself

Abstract

Endometrosis is a reproductive pathology that is responsible for mare infertility. Our recent studies have focused on the involvement of neutrophil extracellular traps enzymes, such as elastase (ELA), in the development of equine endometrosis. Noscapine (NOSC) is an alkaloid derived from poppy opium with anticough, antistroke, anticancer, and antifibrotic properties. The present work investigates the putative inhibitory in vitro effect of NOSC on collagen type I alpha 2 chain (

Indexed as

AnimalsCollagenCollagen Type IEndometriosisEndometriumEstrous CycleExtracellular TrapsFemaleFibrosisHorse DiseasesHorsesNoscapinePancreatic ElastaseProtease InhibitorsCollagenCollagen Type INoscapinePancreatic ElastaseProtease Inhibitorscollagenelastaseendometrosisequinefibrosisinhibitionnoscapine

Identifiers

PMID34069423
PMCPMC8159119
OpenAlexW3162951389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.