ArticleAntibiotics (Basel, Switzerland)2021
Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria.
Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Discovery of MBL-AB01: a novel antibacterial xanthone antibiotic with high activity against methicillin-resistantApplied and environmental microbiology · 2026Article
- Antibiotic Alternatives and Next-Generation Therapeutics forAntibiotics (Basel, Switzerland) · 2025Review
- Natural product-based inhibitors of quorum sensing: A novel approach to combat antibiotic resistance.Biochemistry and biophysics reports · 2025Review
- Physicochemical Profile of Canastra Cheese Inoculated with Starter Cultures ofFoods (Basel, Switzerland) · 2025Article
- Antibacterial Potential of Symmetrical Twin-Drug 3,6-Diaminoxanthones.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections.Antibiotics (Basel, Switzerland) · 2024Review
- Efflux pumps as potential targets for biofilm inhibition.Frontiers in microbiology · 2024Review
- Effect of Indole-Containing Pyrazino[2,1-Antibiotics (Basel, Switzerland) · 2023Article
- Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil.Antibiotics (Basel, Switzerland) · 2023Review
- Article
- Derivatives of Trimethoxybenzoic Acid and Gallic Acid as Potential Efflux Pump Inhibitors: In Silico and In Vitro Studies.International journal of molecular sciences · 2022Article
- New Chalcone-Triazole Hybrids with Promising Antimicrobial Activity in Multidrug Resistance Strains.International journal of molecular sciences · 2022Article
- BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections.Marine drugs · 2022Article
- Inhibition of Quorum-Sensing Regulator fromMolecules (Basel, Switzerland) · 2022Article
- Evaluation of the Antimicrobial and Antivirulent Potential of Essential Oils Isolated fromMicroorganisms · 2022Article
- Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants.Marine drugs · 2021Article
- Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The emergence of multidrug and extensively drug-resistant pathogenic bacteria able to resist to the action of a wide range of antibiotics is becoming a growing problem for public health. The search for new compounds with the potential to help in the reversion of bacterial resistance plays an important role in current medicinal chemistry research. Under this scope, bacterial efflux pumps are responsible for the efflux of antimicrobials, and their inhibition could reverse resistance. In this study, the multidrug resistance reversing activity of a series of xanthones was investigated. Firstly, docking studies were performed in the AcrAB-TolC efflux pump and in a homology model of the NorA pump. Then, the effects of twenty xanthone derivatives on bacterial growth were evaluated in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.