ArticleJournal of clinical medicine2021
Should We Stop Collecting the Preoperative Autologous Blood before Bone Marrow Harvest?
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Supportive Care of Hematopoietic Stem Cell Donors.Clinical hematology international · 2024Article
- Small volume bone marrow aspirates with high progenitor cell concentrations maximize cell therapy dose manufacture and substantially reduce donor hemoglobin loss.BMC medicine · 2023Article
- A survey on preoperative autologous blood donation policy in bone marrow stem cell donors in Italy.Blood transfusion = Trasfusione del sangue · 2023Article
- Progress in Hematopoietic Stem Cell Transplantation and Cellular Therapies.Journal of clinical medicine · 2022Article
- Patient Blood Management in pediatric and adolescent bone marrow donors: results from an Italian survey.Blood transfusion = Trasfusione del sangueArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Preoperative autologous blood donation (PAD) in bone marrow (BM) donors is performed to meet potential post-harvest transfusion needs and to avoid the risk of allogeneic transfusions. We reviewed retrospectively bone marrow harvests in 216 healthy donors during a ten-year period to determine the use of autologous blood. All donors except four had undergone PAD. The initial hemoglobin level of 153 g/L (male donors) and 135 g/L (female donors), respectively, decreased by about 8 g/L after preoperative blood donation and by 23 g/L after bone marrow harvest (medians). Autologous blood was administered to 70% of donors, 30% of the units remained unused. The evaluation of the risk of reaching transfusion threshold (<115 g/L males, <105 g/L females) revealed that donors with initial hemoglobin above 145 g/L and those weighing above 75 kg have minimal risk of requiring blood substitution (about 10%). A larger volume of bone marrow was obtained from male compared to female donors (1300 vs. 1100 mL) because of their higher body weight, which resulted in a higher number of procured nucleated cells (362 vs. 307 × 10
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