Evidence map›Paper›PMID 34069208›Full record

ArticleCancers2021

Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?

JooYong Park, Ji-Yeob Choi, Jaesung Choi, Seokang Chung, Nan Song, Sue K Park, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Jong Won Lee and 83 more

Abstract read
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In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

93 authors.

JooYong ParkDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea.
Ji-Yeob ChoiDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea.
Jaesung ChoiInstitute of Health Policy and Management, Seoul National University Medical Research Center, Seoul 03080, Korea.
Seokang ChungDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea.
Nan SongCollege of Pharmacy, Chungbuk National University, Cheongju-si 28160, Korea.ORCID 0000-0002-9182-1060
Sue K ParkDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea.ORCID 0000-0001-5002-9707
Wonshik HanCancer Research Institute, Seoul National University, Seoul 03080, Korea.
Dong-Young NohCancer Research Institute, Seoul National University, Seoul 03080, Korea.
Sei-Hyun AhnDepartment of Surgery, Medicine and ASAN Medical Center, University of Ulsan College, Seoul 05505, Korea.
Jong Won LeeDepartment of Surgery, Medicine and ASAN Medical Center, University of Ulsan College, Seoul 05505, Korea.
Mi Kyung KimDivision of Cancer Epidemiology and Management, National Cancer Center, Goyang-si 10408, Korea.ORCID 0000-0001-5279-4162
Sun Ha JeeDepartment of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Korea.
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.ORCID 0000-0003-4591-1214
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.ORCID 0000-0001-7065-1237
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Don M ConroyCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Patricia A HarringtonCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Rebecca MayesCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65 Stockholm, Sweden.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0002-5640-9126
Lauren R TerasDepartment of Population Science, American Cancer Society, Atlanta, GA 30303, USA.
Alpa V PatelDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Janet E OlsonDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Elinor J SawyerSchool of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London SE1 9RT, UK.
Rebecca RoylanceDepartment of Oncology, UCLH Foundation Trust, London NW1 2PG, UK.
Stig E BojesenCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
Henrik FlygerDepartment of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
Diether LambrechtsVIB Center for Cancer Biology, 3001 Leuve, Belgium.
Adinda BatenDepartment of Radiotherapy Oncology, KU Leuven-University of Leuven, University Hospitals Leuven, 3000 Leuven, Belgium.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.ORCID 0000-0003-1761-6314
Hidemi ItoDivision of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0002-8023-4581
Pascal GuénelCenter for Research in Epidemiology and Population Health (CESP), Team Exposome and Heredity, INSERM, University Paris-Saclay, 94805 Villejuif, France.
Thérèse TruongCenter for Research in Epidemiology and Population Health (CESP), Team Exposome and Heredity, INSERM, University Paris-Saclay, 94805 Villejuif, France.
Renske KeemanDivision of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0002-5452-9933
Marjanka K SchmidtDivision of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0002-2228-429X
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Chiu-Chen TsengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Angela CoxSheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2TN, UK.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2TN, UK.
kConFab InvestigatorsPeter MacCallum Cancer Center, Melbourne, VIC 3000, Australia.
Irene L AndrulisFred A, Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia.
Pei-Ei WuTaiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Chen-Yang ShenInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Peter A FaschingDepartment of Medicine Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-4885-8471
Arif B EkiciInstitute of Human Genetics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Kenneth MuirDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.
Artitaya LophatananonDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-6129-1572
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0001-9320-8684
Michael E JonesDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
Reiner HoppeDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.
Yon-Dschun KoDepartment of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53177 Bonn, Germany.
Mikael HartmanSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
Jingmei LiHuman Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
Arto MannermaaTranslational Cancer Research Area, University of Eastern Finland, 70210 Kuopio, Finland.
Jaana M HartikainenTranslational Cancer Research Area, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0001-8267-1905
Javier BenitezBiomedical Network on Rare Diseases (CIBERER), 28029 Madrid, Spain.
Anna González-NeiraHuman Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Thilo DörkGynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-9458-0282
Natalia V BogdanovaGynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-9736-4593
Soo Hwang TeoBreast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya 47500, Malaysia.
Nur Aishah Mohd TaibBreast Cancer Research Unit, University Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Olivia FletcherThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW7 3RP, UK.
Nichola JohnsonThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW7 3RP, UK.ORCID 0000-0002-8230-5662
Mervi GripDepartment of Surgery, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, 90570 Oulu, Finland.
Carl BlomqvistDepartment of Oncology, Helsinki University Hospital, University of Helsinki, 00290 Helsinki, Finland.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, 00290 Helsinki, Finland.ORCID 0000-0002-0916-2976
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.
Camilla WendtDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, 118 83 Stockholm, Sweden.
Vessela N KristensenDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.
Nbcs CollaboratorsDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.
Rob A E M TollenaarDepartment of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Bernadette A M Heemskerk-GerritsenDepartment of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0002-9724-6693
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.
Bernardo BonanniDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0003-3589-2128
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Mehdi ManoochehriMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
James V LaceyDepartment of Computational and Quantitative Medicine, City of Hope, Duarte, CA 91010, USA.
Maria Elena MartinezMoores Cancer Center, University of California San Diego, La Jolla, CA 92037, USA.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.
Keun-Young YooDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
Daehee KangDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea.

Funding

Cancer Research UK 16563Wellcome Trust 203477/Z/16/Z
6 · The paper itself

Abstract

In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (

Indexed as

breast cancerestrogengene-environment interaction

Identifiers

PMID34069208
PMCPMC8156547

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.