ReviewMolecules (Basel, Switzerland)2021
Propolis Extract and Its Bioactive Compounds-From Traditional to Modern Extraction Technologies.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Anti-wrinkle efficacy of standardized phenolic acids polymer extract (PAPE) from propolis: Implications for antiaging and skin health.Journal of cosmetic dermatology · 2024Trial
- Exploring the Anti-Inflammatory Potential of Saudi Propolis Through Phytochemical Characterization, Molecular Docking, and Dynamic Simulation.Pharmaceutics · 2026Article
- Preparation and Characterization of Propolis-Biopolymer Coatings on Textiles for Topical Applications: Chemical Composition, Bioactivity, and Cytotoxicity Assessment.Molecules (Basel, Switzerland) · 2026Article
- Valorization of Vegetable Processing Residues for Functional Biodegradable Films in Sustainable Food Packaging.Foods (Basel, Switzerland) · 2026Review
- Evaluation of Propolis and Diclofenac Sodium Eye Drops for Animals: Physicochemical Properties and In Vitro Biological Activity.Gels (Basel, Switzerland) · 2026Article
- Wound-Healing Effects of Birch Bark and Propolis Extracts on Epidermolysis Bullosa Keratinocytes.International journal of molecular sciences · 2026Article
- Propolis: A Natural Bioactive Compound with Emerging Roles in Functional Food Applications.International journal of molecular sciences · 2026Review
- Comparative Evaluation of the Antidiabetic, Hypolipidemic and Antioxidant Effects ofMolecules (Basel, Switzerland) · 2026Article
- Characterization of Heterotrigona itama Propolis Extracts: Phytochemicals and Thermal Insights.Chemistry & biodiversity · 2026Article
- In Situ ThaiPharmaceuticals (Basel, Switzerland) · 2026Article
- Protective Effects of a Propolis-Journal of microbiology and biotechnology · 2026Article
- Antiviral and Anticancer Activities of Stingless Bee Propolis fromInternational journal of molecular sciences · 2026Article
- Chihuahuan Propolis as a Non-Antibiotic Intracanal Agent AgainstMicroorganisms · 2026Article
- Propolis in Obesity and Related Metabolic Disorders: Mechanistic and Clinical Insights-A Scoping Review.Nutrients · 2026Article
- Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti-Wrinkle Efficacy.Journal of cosmetic dermatology · 2026Article
- 2-Hydroxypropyl-β-Cyclodextrin-Based Complexes Improve Polyphenol Solubility and Bioaccessibility: Evaluation by Validated HPLC-DAD Method.Molecules (Basel, Switzerland) · 2026Article
- Investigation of Antioxidant Properties of Propolis Products Collected from Different Regions.International journal of molecular sciences · 2026Article
- Antimicrobial activity of brown propolis ethanolic extract and its application in intramammary formulation for the treatment of bovine mastitis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Alleviation of Aflatoxin B1-Induced Hepatic Damage by Propolis: Effects on Inflammation, Apoptosis, and Cytochrome P450 Enzyme Expression.Current issues in molecular biology · 2026Article
- Inhibition of the PKC-TRPV1-SP axis by propolis ameliorates chronic inflammatory pain in mice.Iranian journal of basic medical sciences · 2026Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propolis is a honeybee product known for its antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. It is rich in bioactive molecules whose content varies depending on the botanical and geographical origin of propolis. These bioactive molecules have been studied individually and as a part of propolis extracts, as they can be used as representative markers for propolis standardization. Here, we compare the pharmacological effects of representative polyphenols and whole propolis extracts. Based on the literature data, polyphenols and extracts act by suppressing similar targets, from pro-inflammatory TNF/NF-κB to the pro-proliferative MAPK/ERK pathway. In addition, they activate similar antioxidant mechanisms of action, like Nrf2-ARE intracellular antioxidant pathway, and they all have antimicrobial activity. These similarities do not imply that we should attribute the action of propolis solely to the most representative compounds. Moreover, its pharmacological effects will depend on the efficacy of these compounds' extraction. Thus, we also give an overview of different propolis extraction technologies, from traditional to modern ones, which are environmentally friendlier. These technologies belong to an open research area that needs further effective solutions in terms of well-standardized liquid and solid extracts, which would be reliable in their pharmacological effects, environmentally friendly, and sustainable for production.
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Registered trials
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