Evidence map›Paper›PMID 34068969›Full record

ArticleMolecules (Basel, Switzerland)2021

Enhancement of the Antioxidant and Antimicrobial Activities of Porphyran through Chemical Modification with Tyrosine Derivatives.

Pedro Adão, João Reboleira, Marco Teles, Beatriz Santos, Nádia Ribeiro, Carlos M Teixeira, Mafalda Guedes, João Costa Pessoa, Susana Bernardino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Seasonal Nutritional Profile ofFoods (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pedro AdãoMARE, Politécnico de Leiria, Edifício CETEMARES, Av. Porto de Pesca, 2520-630 Peniche, Portugal.ORCID 0000-0002-7216-0260
João ReboleiraMARE, Politécnico de Leiria, Edifício CETEMARES, Av. Porto de Pesca, 2520-630 Peniche, Portugal.ORCID 0000-0003-3261-6857
Marco TelesMARE, Politécnico de Leiria, Edifício CETEMARES, Av. Porto de Pesca, 2520-630 Peniche, Portugal.ORCID 0000-0002-5601-9849
Beatriz SantosMARE, Politécnico de Leiria, Edifício CETEMARES, Av. Porto de Pesca, 2520-630 Peniche, Portugal.
Nádia RibeiroCentro Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.ORCID 0000-0003-2725-7781
Carlos M TeixeiraCentro Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.ORCID 0000-0002-7303-3570
Mafalda GuedesCDP2T and Department of Mechanical Engineering, Escola Superior de Tecnologia de Setúbal, Instituto Politécnico de Setúbal, 2910-761 Setúbal, Portugal.
João Costa PessoaCentro Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.ORCID 0000-0002-3978-9964
Susana BernardinoMARE, Escola Superior de Turismo e Tecnologia do Mar, Politécnico de Leiria, Av. Porto de Pesca, 2520-630 Peniche, Portugal.
Instituto Politécnico de Leiria · PTUniversity of Lisbon · PT

Funding

Fundação para a Ciência e a Tecnologia PD/BD/106078/2015Fundação para a Ciência e a Tecnologia SFRH/BD/135797/2018
6 · The paper itself

Abstract

The chemical modification of porphyran hydrocolloid is attempted, with the objective of enhancing its antioxidant and antimicrobial activities. Sulfated galactan porphyran is obtained from commercial samples of the red algae Porphyra dioica using Soxhlet extraction with water at 100 °C and precipitation with isopropyl alcohol. The extracted porphyran is then treated with modified L-tyrosines in aqueous medium in the presence of NaOH, at ca. 70 °C. The modified tyrosines L1 and L2 are prepared through a Mannich reaction with either thymol or 2,4-di-tert-butylphenol, respectively. While the reaction with 2,4-di-tert-butylphenol yields the expected tyrosine derivative, a mixture of products is obtained with thymol. The resulting polysaccharides are structurally characterized and the respective antioxidant and antimicrobial activities are determined. Porphyran treated with the N-(2-hydroxy-3,5-di-tert-butyl-benzyl)-L-tyrosine derivative, POR-L2, presents a noticeable superior radical scavenging and antioxidant activity compared to native porphyran, POR. Furthermore, it exhibited some antimicrobial activity against

Indexed as

AerobiosisAnti-Infective AgentsAntioxidantsBenzothiazolesBiphenyl CompoundsEscherichia coliMicrobial Sensitivity TestsOxidation-ReductionPicratesPorphyraProton Magnetic Resonance SpectroscopySepharoseSpectrophotometry, UltravioletSpectroscopy, Fourier Transform InfraredStaphylococcus aureusSulfonic Acids1,1-diphenyl-2-picrylhydrazyl2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidAnti-Infective AgentsAntioxidantsBenzothiazolesBiphenyl CompoundsPicratesporphyranSepharoseSulfonic AcidsTyrosineantimicrobial activityantioxidant activitymodified porphyran

Identifiers

PMID34068969
PMCPMC8156949
OpenAlexW3161285566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.