Evidence map›Paper›PMID 34068941›Full record

ArticleInternational journal of molecular sciences2021

Inhibition of Lysine 63 Ubiquitination Prevents the Progression of Renal Fibrosis in Diabetic DBA/2J Mice.

Paola Pontrelli, Francesca Conserva, Rossella Menghini, Michele Rossini, Alessandra Stasi, Chiara Divella, Viviana Casagrande, Claudia Cinefra, Mariagrazia Barozzino, Simona Simone and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Post‑translational modifications in diabetic kidney disease (Review).International journal of molecular medicine · 2026
    Review
  2. Review
  3. Article
  4. The Role of Non-Coding RNAs in Kidney Diseases.International journal of molecular sciences · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Paola PontrelliDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-7654-8318
Francesca ConservaDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.ORCID 0000-0003-2863-864X
Rossella MenghiniDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Michele RossiniDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Alessandra StasiDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.ORCID 0000-0003-3652-3623
Chiara DivellaDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Viviana CasagrandeDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-3554-0181
Claudia CinefraDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Mariagrazia BarozzinoDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Simona SimoneDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Francesco PesceDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Giuseppe CastellanoDepartment of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Giovanni StalloneDepartment of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Anna GalloneDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-2252-9584
Francesco GiorginoDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.ORCID 0000-0001-7372-2678
Massimo FedericiDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Loreto GesualdoDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
University of Bari Aldo Moro · ITUniversity of Rome Tor Vergata · ITUniversity of Foggia · IT

Funding

Innovative Medicines Initiative grant agreement No 115974
6 · The paper itself

Abstract

Diabetic nephropathy (DN) is the most frequent cause of end-stage renal disease. Tubulointerstitial accumulation of lysine 63 (K63)-ubiquitinated (Ub) proteins is involved in the progression of DN fibrosis and correlates with urinary miR-27b-3p downregulation. We explored the renoprotective effect of an inhibitor of K63-Ub (NSC697923), alone or in combination with the ACE-inhibitor ramipril, in vitro and in vivo. Proximal tubular epithelial cells and diabetic DBA/2J mice were treated with NSC697923 and/or ramipril. K63-Ub protein accumulation along with α-SMA, collagen I and III, FSP-1, vimentin, p16

Indexed as

UbiquitinationAngiotensin-Converting Enzyme InhibitorsAnimalsDiabetes Mellitus, ExperimentalDiabetic NephropathiesDrug Therapy, CombinationFemaleFibrosisLysineMiceMice, Inbred DBANitrofuransRamiprilSulfones2-((4-methylphenyl)sulfonyl)-5-nitrofuranAngiotensin-Converting Enzyme InhibitorsLysineNitrofuransRamiprilSulfonesDBA2/J micediabeteslysine 63 ubiquitinationmicroRNArenal fibrosissenescence

Identifiers

PMID34068941
PMCPMC8157080
OpenAlexW3161941600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.