Evidence map›Paper›PMID 34068867›Full record

ArticleJournal of clinical medicine2021

Alterations in Respiratory Function Test Three Months after Hospitalisation for COVID-19 Pneumonia: Value of Determining Nitric Oxide Diffusion.

Marta Núñez-Fernández, Cristina Ramos-Hernández, Francisco García-Río, María Torres-Durán, Andrés Nodar-Germiñas, Amara Tilve-Gómez, Paula Rodríguez-Fernández, Diana Valverde-Pérez, Alberto Ruano-Raviña, Alberto Fernández-Villar

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2025
    Pooled it
  3. Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  4. Clinical predictors of impaired pulmonary diffusing capacity in patients recovering from COVID-19: A secondary analysis of multicentre datasets.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026
    Article
  5. Pulmonary diffusing capacity for nitric oxide in disease: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Systematic Review of the Prevalence of Long COVID.Open forum infectious diseases · 2023
    Article
  11. Reply to Noel-Savina and collaborators: DRespiratory medicine and research · 2023
    Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Observational
  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marta Núñez-FernándezService of Pneumology, University Hospital Complex of Vigo, NeumoVigo I+i. Institute of Health Research South Galicia (IISGS), 36213 Vigo, Spain.ORCID 0000-0001-9088-3713
Cristina Ramos-HernándezService of Pneumology, University Hospital Complex of Vigo, NeumoVigo I+i. Institute of Health Research South Galicia (IISGS), 36213 Vigo, Spain.ORCID 0000-0001-5626-7810
Francisco García-RíoService of Pneumology La Paz-IdiPAZ University Hospital, 28046 Madrid, Spain.ORCID 0000-0002-7227-2238
María Torres-DuránService of Pneumology, University Hospital Complex of Vigo, NeumoVigo I+i. Institute of Health Research South Galicia (IISGS), 36213 Vigo, Spain.
Andrés Nodar-GermiñasInfectious Diseases Unit, Service of Internal Medicine, University Hospital Complex of Vigo, 36213 Vigo, Spain.
Amara Tilve-GómezService of Radiodiagnosis, University Hospital Complex of Vigo, 36213 Vigo, Spain.
Paula Rodríguez-FernándezService of Radiodiagnosis, University Hospital Complex of Vigo, 36213 Vigo, Spain.
Diana Valverde-PérezDepartment of Biochemistry, Genetics and Immunology, University of Vigo, 36310 Vigo, Spain.ORCID 0000-0002-7024-1657
Alberto Ruano-RaviñaDepartment of Preventive Medicine and Public Health, University of Santiago de Compostela, 15704 Santiago de Compostela, Spain.ORCID 0000-0001-9927-7453
Alberto Fernández-VillarService of Pneumology, University Hospital Complex of Vigo, NeumoVigo I+i. Institute of Health Research South Galicia (IISGS), 36213 Vigo, Spain.ORCID 0000-0001-7407-5249

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three to four months after hospitalisation for COVID-19 pneumonia, the most frequently described alteration in respiratory function tests (RFTs) is decreased carbon monoxide transfer capacity (DL

methodsThis is a prospective cohort study that included patients hospitalised because of SARS-CoV-2 pneumonia, three months after their discharge. A clinical evaluation, analytical parameters, chest X-ray, six-minute walk test, spirometry and DL

resultsTwo hundred patients completed the study; 59.5% men, age 62 years, 15.5% admitted to the intensive care unit. The most frequent functional alteration, in 27% of patients, was in the DL

conclusionsThe most sensitive RFT for the detection of the sequelae of COVID-19 pneumonia was the combined measurement of DL

Indexed as

COVID-19diffusion capacityDLCODLNOpneumoniarespiratory function testssequelae

Identifiers

PMID34068867
PMCPMC8153552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.