Evidence map›Paper›PMID 34068785›Full record

ReviewJournal of clinical medicine2021

Genital Tract GAS Infection ISIDOG Guidelines.

Gilbert Donders, Peter Greenhouse, Francesca Donders, Ulrike Engel, Jorma Paavonen, Werner Mendling

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Analysis ofmBio · 2025
    Article
  5. Polish journal of microbiology · 2025
    Article
  6. Article
  7. [Streptococcus pyogenes vulvovaginitis in adult women].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Molecular Characteristics ofFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gilbert DondersFemicare, Clinical Research for Women, 3300 Tienen, Belgium.ORCID 0000-0001-9890-6254
Peter GreenhouseClifton Women's Health, Bristol BS6 6JD, UK.
Francesca DondersFemicare, Clinical Research for Women, 3300 Tienen, Belgium.ORCID 0000-0003-0376-0067
Ulrike EngelDepartment of Ob/Gyn Maternité, Centre Hospitalier, 1210 Luxembourg, Luxembourg.
Jorma PaavonenDepartment of Obstetrics and Gynecology, Helsinki University Hospital, 00260 Helsinki, Finland.
Werner MendlingGerman Centre for Infections in Gynecology and Obstetrics, at Helios University Hospital Wuppertal, 42283 Wuppertal, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been an increasing worldwide incidence of invasive group A streptococcal (GAS) disease in pregnancy and in the puerperal period over the past 30 years. Postpartum Group A streptococci infection, and in particular streptococcal toxic shock syndrome (TSS) and necrotizing fasciitis, can be life threatening and difficult to treat. Despite antibiotics and supportive therapy, and in some cases advanced extensive surgery, mortality associated with invasive group A streptococcal postpartum endometritis, necrotizing fasciitis, and toxic shock syndrome remains high, up to 40% of postpartum septic deaths. It now accounts for more than 75,000 deaths worldwide every year. Postpartum women have a 20-fold increased incidence of GAS disease compared to non-pregnant women. Despite the high incidence, many invasive GAS infections are not diagnosed in a timely manner, resulting in potentially preventable maternal and neonatal deaths. In this paper the specific characteristics of GAS infection in the field of Ob/Gyn are brought to our attention, resulting in guidelines to improve our awareness, early recognition and timely treatment of the disease. New European prevalence data of vaginal GAS colonization are presented, alongside two original case histories. Additionally, aerobic vaginitis is proposed as a supplementary risk factor for invasive GAS diseases.

Indexed as

endometritisinvasive GAS infectionmaternal mortalitypuerperal infectionsepsisStreptococcus pyogenes

Identifiers

PMID34068785
PMCPMC8126195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.