Evidence map›Paper›PMID 34068774›Full record

ReviewCancers2021

Defining the Criteria for Reflex Testing for

Sarah Zhou, Daniel Sikorski, Honghao Xu, Andrei Zubarev, May Chergui, François Lagacé, Wilson H Miller, Margaret Redpath, Stephanie Ghazal, Marcus O Butler and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sarah ZhouDivision of Dermatology, McGill University, Montreal, QC H3A 0G4, Canada.ORCID 0000-0002-9351-8487
Daniel SikorskiDivision of Dermatology, McGill University, Montreal, QC H3A 0G4, Canada.
Honghao XuDivision of Dermatology, Laval University, Quebec City, QC G1V 0A6, Canada.
Andrei ZubarevDivision of Dermatology, McGill University, Montreal, QC H3A 0G4, Canada.
May CherguiDepartment of Pathology, McGill University, Montreal, QC H3A 0G4, Canada.
François LagacéDivision of Dermatology, McGill University, Montreal, QC H3A 0G4, Canada.ORCID 0000-0002-9033-2302
Wilson H MillerDepartments of Medicine and Oncology, McGill University, Montreal, QC H3A 0G4, Canada.
Margaret RedpathDepartment of Pathology, McGill University, Montreal, QC H3A 0G4, Canada.
Stephanie GhazalDivision of Dermatology, McGill University, Montreal, QC H3A 0G4, Canada.
Marcus O ButlerPrincess Margaret Cancer Centre, Department of Medical Oncology and Hematology, University of Toronto, Toronto, ON M5G 2C1, Canada.ORCID 0000-0002-9840-7057
Teresa M PetrellaOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada.
Joël ClaveauDivision of Dermatology, Laval University, Quebec City, QC G1V 0A6, Canada.
Carolyn NessimDivision of General Surgery, University of Ottawa, Ottawa, ON K1N 6N5, Canada.ORCID 0000-0002-0419-3511
Thomas G SalopekDivision of Dermatology, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0001-6990-8680
Robert GniadeckiDivision of Dermatology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Ivan V LitvinovDivision of Dermatology, McGill University, Montreal, QC H3A 0G4, Canada.ORCID 0000-0003-0562-4675

Funding

Canadian Dermatology Foundation N/ACanadian Institutes for Health Research 426655Canadian Institutes for Health Research 428712Cancer Research Society 25343Fonds de la recherche du Québec - Santé grants 34753Fonds de la recherche du Québec - Santé grants 36769
6 · The paper itself

Abstract

Targeted therapy has been developed through an in-depth understanding of molecular pathways involved in the pathogenesis of melanoma. Approximately ~50% of patients with melanoma have tumors that harbor a mutation of the

Indexed as

advanced melanomaBRAF inhibitorBRAF mutationMAPK pathwaymetastatic melanomareflex testingstage IItargeted therapy

Identifiers

PMID34068774
PMCPMC8126223

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.