Evidence map›Paper›PMID 34068719›Full record

ArticleCells2021

Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9.

Hsueh-Yao Chu, Chih-Yung Yang, Ping-Hao Yeh, Chun-Jieh Hsu, Lu-Wei Chang, Wei-Jen Chan, Chien-Ping Lin, You-You Lyu, Wei-Cheng Wu, Chun-Wei Lee and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Hsueh-Yao ChuDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
Chih-Yung YangDepartment Education Research, Taipei City Hospital, Taipei 10341, Taiwan.
Ping-Hao YehDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
Chun-Jieh HsuDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
Lu-Wei ChangDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
Wei-Jen ChanDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
Chien-Ping LinInstitute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei 11221, Taiwan.
You-You LyuInstitute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei 11221, Taiwan.
Wei-Cheng WuDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
Chun-Wei LeeDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
Jen-Kuei WuDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
Jeng-Kai JiangDepartment of Surgery, Division of Colorectal Surgery, Taipei Veterans General Hospital, Taiwan School of Medicine, National Yang-Ming Chiao-Tung University, Taipei 11217, Taiwan.
Fan-Gang TsengDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.ORCID 0000-0001-7654-6905
National Tsing Hua University · TWNational Yang Ming Chiao Tung University · TWChang Gung University · TWNational United University · TW

Funding

Ministry of Science and Technology MOST-104-2221-E-007-072-MY3 ;MOST-107-2221-E-007-012-MY3 ;MOST-107-3017-F-007-002, 108-2638-E-007-001-MY2, 108-3017-F-007-0032Veterans General Hospitals and University System of Taiwan Joint Research Program VGHUST107-G6-1-1
6 · The paper itself

Abstract

Circulation tumor cells (CTCs) play an important role in metastasis and highly correlate with cancer progression; thus, CTCs could be considered as a powerful diagnosis tool. Our previous studies showed that the number of CTCs could be utilized for recurrence prediction in colorectal cancer (CRC); however, the odds ratio was still lower than five. To improve prognosis in CRC patients, we analyzed CTC clusters/microemboli, CTC numbers, and carcinoembryonic antigen (CEA)/carbohydrate antigen 19-9 (CA19-9) levels using a self-assembled cell array (SACA) chip system for recurrence prediction. In CRC patients, the presence of CTC clusters/microemboli may have higher correlation in metastasis when compared to the high number of CTCs. Additionally, when both the number of CTCs and serum CEA levels are high, very high odds ratios of 24.4 and 17.1 are observed in patients at all stages and stage III of CRC, respectively. The high number of CTCs and CTC clusters/microemboli simultaneously suggests the high chance of relapse (odds ratio 8.4). Overall, the characteristic of CTC clusters/microemboli, CEA level, and CTC number have a clinical potential to enhance CRC prognosis.

Indexed as

PrognosisAgedAlgorithmsBiomarkers, TumorCA-19-9 AntigenCarcinoembryonic AntigenColorectal NeoplasmsEmbolismFemaleHumansImmunoassayKaplan-Meier EstimateLiquid BiopsyLymphatic MetastasisMaleMicroscopy, FluorescenceBiomarkers, TumorCA-19-9 AntigenCarcinoembryonic Antigencirculating tumor cell (CTC)circulating tumor microemboli (CTM)colorectal cancer (CRC)CTC clustersliquid biopsyprognostic analysis

Identifiers

PMID34068719
PMCPMC8151024
OpenAlexW3162006695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.