Evidence map›Paper›PMID 34068627›Full record

ArticleMolecules (Basel, Switzerland)2021

α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer.

Yohei Saito, Atsushi Mizokami, Kouji Izumi, Renato Naito, Masuo Goto, Kyoko Nakagawa-Goto

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yohei SaitoSchool of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Science, Kanazawa University, Kanazawa 920-1192, Japan.
Atsushi MizokamiDepartment of Integrative Cancer Therapy and Urology, School of Medical Sciences, Kanazawa University, Kanazawa 920-1192, Japan.ORCID 0000-0002-5643-2182
Kouji IzumiDepartment of Integrative Cancer Therapy and Urology, School of Medical Sciences, Kanazawa University, Kanazawa 920-1192, Japan.
Renato NaitoDepartment of Integrative Cancer Therapy and Urology, School of Medical Sciences, Kanazawa University, Kanazawa 920-1192, Japan.
Masuo GotoChemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-9659-1460
Kyoko Nakagawa-GotoSchool of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Science, Kanazawa University, Kanazawa 920-1192, Japan.ORCID 0000-0002-1642-6538
Kanazawa University · JPUniversity of North Carolina at Chapel Hill · US

Funding

IBM junior faculty grant NAJapan Society for the Promotion of Science 25293024, 17H04325
6 · The paper itself

Abstract

α-Trifluoromethyl chalcones were prepared and evaluated for their antiproliferative activities against androgen-independent prostate cancer cell lines as well as five additional types of human tumor cell lines. The most potent chalcone

Indexed as

AnimalsAntineoplastic AgentsCell CycleCell Line, TumorCell ProliferationChalconesDocetaxelHumansMaleMiceMice, SCIDProstatic NeoplasmsReceptors, AndrogenTaxoidsXenograft Model Antitumor AssaysAntineoplastic AgentscabazitaxelChalconesDocetaxelReceptors, AndrogenTaxoidsantitumor activitychalconeprostate cancertarget proteinstrifluoromethyl group

Identifiers

PMID34068627
PMCPMC8126091
OpenAlexW3161489179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.