ArticleBrain sciences2021
Many Faces of the Hidden Souls: Medical and Neurological Complications and Comorbidities in Disorders of Consciousness.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Advances in biomarkers for diagnosing and prognosticating disorders of consciousness.Frontiers in neuroscience · 2026Review
- Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable.Intensive care medicine · 2026Review
- Influencing factors of hospitalization costs for intensive rehabilitation in patients with post-stroke disorder of consciousness.Frontiers in public health · 2025Article
- Article
- Exploring end-of-life decision-making in China for disorders of consciousness.Annals of medicine · 2024Article
- Cognitive Motor Dissociation: Gap Analysis and Future Directions.Neurocritical care · 2024Article
- Assessment of Frequency and Predictive Value of Comorbidities in Patients With Disorders of Consciousness in the Acute Setting.Neurotrauma reports · 2024Article
- Sleep in Disorders of Consciousness: A Brief Overview on a Still under Investigated Issue.Brain sciences · 2023Review
- Clinical application of recommendations for neurobehavioral assessment in disorders of consciousness: an interdisciplinary approach.Frontiers in human neuroscience · 2023Review
- Specialized intensive inpatient rehabilitation is crucial and time-sensitive for functional recovery from disorders of consciousness.Frontiers in neurology · 2023Article
- Frequency and Characteristics of Medical Complications in Rehabilitation Settings: A Scoping Review.Journal of rehabilitation medicine · 2022Article
- Long-term outcomes of post-cardiac arrest patients with severe neurological and functional impairments at hospital discharge.Resuscitation · 2022Article
- A Retrospective Analysis on Clinical Practice-Based Approaches Using Zolpidem and Lorazepam in Disorders of Consciousness.Brain sciences · 2021Article
- Effectiveness of coma arousal therapy on patients with disorders of consciousness - A systematic review and meta-analysis.Brain circulationReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early and goal-directed management of complications and comorbidities is imperative to facilitate neurorecovery and to optimize outcomes of disorders of consciousness (DoC). This is the first large retrospective cohort study on the primary medical and neurological complications and comorbidities in persons with DoC. A total of 146 patients admitted to a specialized inpatient DoC rehabilitation program from 1 January 2014 to 31 October 2018 were included. The incidences of those conditions since their initial brain injuries were reviewed per documentation. They were categorized into reversible causes of DoC, confounders and mimics, and other medical/neurological conditions. The common complications and comorbidities included pneumonia (73.3%), pain (75.3%), pressure ulcers (70.5%), oral and limb apraxia (67.1%), urinary tract infection (69.2%), and 4-limb spasticity (52.7%). Reversible causes of DoC occurred very commonly. Conditions that may confound the diagnosis of DoC occurred at surprisingly high rates. Conditions that may be a source of pain occurred not infrequently. Among those that may diminish or confound the level of consciousness, 4.8 ± 2.0 conditions were identified per patient. In conclusion, high rates of various complications and comorbidities occurred in persons with DoC. Correcting reversible causes, identifying confounders and mimics, and managing general consequences need to be seriously considered in clinical practice.
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