Evidence map›Paper›PMID 34068503›Full record

ArticleBiomedicines2021

Shu-Pin Huang, Yei-Tsung Chen, Lih-Chyang Chen, Cheng-Hsueh Lee, Chao-Yuan Huang, Chia-Cheng Yu, Victor C Lin, Te-Ling Lu, Bo-Ying Bao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Shu-Pin HuangDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Yei-Tsung ChenDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0002-3891-5172
Lih-Chyang ChenDepartment of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.
Cheng-Hsueh LeeDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Chao-Yuan HuangDepartment of Urology, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 100, Taiwan.
Chia-Cheng YuDepartment of Surgery, Division of Urology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.
Victor C LinDepartment of Urology, E-Da Hospital, Kaohsiung 824, Taiwan.
Te-Ling LuDepartment of Pharmacy, China Medical University, Taichung 404, Taiwan.ORCID 0000-0003-1408-6004
Bo-Ying BaoDepartment of Pharmacy, China Medical University, Taichung 404, Taiwan.ORCID 0000-0001-5510-6513
Kaohsiung Medical University · TWNational Yang Ming Chiao Tung University · TWAsia University · TWChina Medical University · TWE-Da Hospital · TWMackay Medical University · TWNational Taiwan University Hospital · TW

Funding

China Medical University, Taiwan CMU108-MF-50, CMU109-SR-64, and CMU109-MF-65Kaohsiung Medical University Chung-Ho Memorial Hospital KMUH105-5R42, KMUH108-8R53 and KMUH108-8R55Kaohsiung Medical University Research Center KMU-TC108A04-4Ministry of Science and Technology, Taiwan 108-2314-B-037-029, 108-2314-B-037-026-MY2, 108-2320-B-039-050-MY3, 109-2314-B-037-108-MY2, and 109-2314-B-037-106-MY3
6 · The paper itself

Abstract

Neuregulins (NRGs) activate receptor tyrosine kinases of the ErbB family, and play essential roles in the proliferation, survival, and differentiation of normal and malignant tissue cells. We hypothesized that genetic variants of NRG signalling pathway genes may influence treatment outcomes in prostate cancer. To test this hypothesis, we performed a comprehensive analysis to evaluate the associations of 459 single-nucleotide polymorphisms in 19 NRG pathway genes with cancer-specific survival (CSS), overall survival (OS), and progression-free survival (PFS) in 630 patients with prostate cancer receiving androgen-deprivation therapy (ADT). After multivariate Cox regression and multiple testing correction, we found that

Indexed as

androgen-deprivation therapymeta-analysisneuregulinprostate cancersurvival

Identifiers

PMID34068503
PMCPMC8151455
OpenAlexW3163582307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.