Evidence map›Paper›PMID 34068315›Full record

ArticleBrain sciences2021

Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients.

Esteban Sarrias-Arrabal, Sara Eichau, Alejandro Galvao-Carmona, Elvira Domínguez, Guillermo Izquierdo, Manuel Vázquez-Marrufo

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Esteban Sarrias-ArrabalExperimental Psychology Department, Faculty of Psychology, University of Seville, 41018 Seville, Spain.ORCID 0000-0003-2050-2668
Sara EichauUnit CSUR Multiple Sclerosis, Hospital Virgen Macarena, 41009 Seville, Spain.
Alejandro Galvao-CarmonaDepartamento de Psicología, Universidad Loyola Andalucía, 41704 Sevilla, Spain.ORCID 0000-0002-5126-1273
Elvira DomínguezUnit of Multiple Sclerosis, FISEVI, Hospital Virgen Macarena, 41009 Seville, Spain.
Guillermo IzquierdoUnit of Multiple Sclerosis, Hospital VITHAS, 41950 Seville, Spain.
Manuel Vázquez-MarrufoExperimental Psychology Department, Faculty of Psychology, University of Seville, 41018 Seville, Spain.ORCID 0000-0002-0456-7165
Hospital Universitario Virgen Macarena · ESUniversidad de Sevilla · ESHospital de Manises · ESUniversidad Loyola Andalucía · ES

Funding

Ministerio de Economía y Competitividad, Government of Spain PSI2016- 78133-P
6 · The paper itself

Abstract

Currently, there is scarce knowledge about the relation between spectral bands modulations and the basis of cognitive impairment in multiple sclerosis (MS). In this sense, analyzing the evoked or phase activity can confirm results from traditional event-related potential (ERP) studies. However, studying the induced or nonphase activity may be necessary to elucidate hidden compensatory or affected cognitive mechanisms. In this study, 30 remitting-relapsing multiple sclerosis patients and 30 healthy controls (HCs) matched in sociodemographic variables performed a visual oddball task. The main goal was to analyze phase and nonphase alpha and gamma bands by applying temporal spectral evolution (TSE) and its potential relation with cognitive impairment in these patients. The behavioural results showed slower reaction time and poorer accuracy in MS patients compared to controls. In contrast, the time-frequency analysis of electroencephalography (EEG) revealed a delay in latency and lower amplitude in MS patients in evoked and induced alpha compared to controls. With respect to the gamma band, there were no differences between the groups. In summary, MS patients showed deficits in early sensorial (evoked alpha activity) and cognitive processing (induced alpha activity in longer latencies), whereas the induced gamma band supported the hypothesis of its role in translation of attentional focus (induced activity) and did not show strong activity in this paradigm (visual oddball).

Indexed as

alphaEEGevokedgammainducedmultiple sclerosisoddball

Identifiers

PMID34068315
PMCPMC8153279
OpenAlexW3161902942

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.