Evidence map›Paper›PMID 34068293›Full record

ReviewMolecules (Basel, Switzerland)2021

Structural Studies Providing Insights into Production and Conformational Behavior of Amyloid-β Peptide Associated with Alzheimer's Disease Development.

Anatoly S Urban, Konstantin V Pavlov, Anna V Kamynina, Ivan S Okhrimenko, Alexander S Arseniev, Eduard V Bocharov

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

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  7. E674Q (ShanghaiGenes & diseases · 2024
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  15. From Menopause to Neurodegeneration-Molecular Basis and Potential Therapy.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Anatoly S UrbanShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Konstantin V PavlovFederal Clinical Center of Physical-Chemical Medicine of FMBA, 119435 Moscow, Russia.
Anna V KamyninaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Ivan S OkhrimenkoResearch Center for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.ORCID 0000-0002-1053-2778
Alexander S ArsenievShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Eduard V BocharovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Moscow Institute of Physics and Technology · RUFederal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin · RUInstitute of Bioorganic Chemistry · RU

Funding

Russian Science Foundation 19-15-00427Russian Science Foundation 20-64-46027
6 · The paper itself

Abstract

Alzheimer's disease is the most common type of neurodegenerative disease in the world. Genetic evidence strongly suggests that aberrant generation, aggregation, and/or clearance of neurotoxic amyloid-β peptides (

Indexed as

Protein ConformationAlzheimer DiseaseAmyloid beta-PeptidesAnimalsHumansProtein AggregatesProtein Interaction MapsProteolysisAmyloid beta-PeptidesProtein AggregatesAlzheimer’s diseaseamyloid precursor proteinamyloid-β peptidebioactive peptides for therapy and diagnosismolecular mechanismneuronal membraneprotein–protein and protein–lipid interactionsstructural–dynamical propertiestoxic oligomerization

Identifiers

PMID34068293
PMCPMC8153327
OpenAlexW3161725775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.