ArticleNanomaterials (Basel, Switzerland)2021
L-Cysteine as an Irreversible Inhibitor of the Peroxidase-Mimic Catalytic Activity of 2-Dimensional Ni-Based Nanozymes.
Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Plasmonic property of gold nanoparticles to predict nanozyme activity: towards the colorimetric detection of manganese(ii).RSC advances · 2026Article
- Covalent Michael-type recognition-based dual-mode sensing platform using thiol-functionalized nitrogen-doped carbon dots and Fe-MOF nanozyme for ultrasensitive patulin detection.Mikrochimica acta · 2026Article
- Physical Processing Controls the Structure, Mesoporosity, and Suspension-Phase Functionality of Nanostructured MnONanomaterials (Basel, Switzerland) · 2026Article
- Nanozyme Aptasensor Array for Predictive Sensing of Virulent and Antibiotic-Resistant Staphylococcus Aureus strains.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Silver-based bimetallic nanozyme fabrics with peroxidase-mimic activity for urinary glucose detection.Analytical and bioanalytical chemistry · 2024Article
- User-friendly and ultra-stable all-inclusive gold tablets for cysteamine detection.RSC advances · 2023Article
- Nanozymes with Peroxidase-like Activity for Ferroptosis-Driven Biocatalytic Nanotherapeutics of Glioblastoma Cancer: 2D and 3D Spheroids Models.Pharmaceutics · 2023Article
- Peroxidase-like activity of biosynthesized silver nanoparticles for colorimetric detection of cysteine.RSC advances · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The ability to modulate the catalytic activity of inorganic nanozymes is of high interest. In particular, understanding the interactions of inhibitor molecules with nanozymes can bring them one step closer to the natural enzymes and has thus started to attract intense interest. To date, a few reversible inhibitors of the nanozyme activity have been reported. However, there are no reports of irreversible inhibitor molecules that can permanently inhibit the activity of nanozymes. In the current work, we show the ability of L-cysteine to act as an irreversible inhibitor to permanently block the nanozyme activity of 2-dimensional (2D) NiO nanosheets. Determination of the steady state kinetic parameters allowed us to obtain mechanistic insights into the catalytic inhibition process. Further, based on the irreversible catalytic inhibition capability of L-cysteine, we demonstrate a highly specific sensor for the detection of this biologically important molecule.
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Registered trials
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