ReviewAntioxidants (Basel, Switzerland)2021
ROS and NO Phytomelatonin-Induced Signaling Mechanisms under Metal Toxicity in Plants: A Review.
Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Toxic Metal in Plant-Based Therapeutics: Contamination Pathways, Oxidative Stress Induction, and Onset of Disease.TheScientificWorldJournal · 2026Pooled it
- Transporter promiscuity and redox-driven metal partitioning in plant responses to chemically analogous metals.Plant cell reports · 2026Review
- From Abiotic Stress to Emerging Environmental Pollutants: Expanding Roles of Melatonin and NO in Plant Defense.International journal of molecular sciences · 2026Review
- Phytomelatonin in Ornamental Horticulture: A Comprehensive Review of Growth Promotion, Stress Tolerance, and Post-Harvest Quality.International journal of molecular sciences · 2026Review
- Melatonin-induced resistance response activation against Fusarium oxysporum f. sp. lycopersici development in tomatoes.Scientific reports · 2025Article
- Review
- Nitric Oxide and Melatonin Cross Talk on Photosynthetic Machinery.Molecules (Basel, Switzerland) · 2025Review
- Exogenous Melatonin Boosts Heat Tolerance inPlants (Basel, Switzerland) · 2024Article
- Crosstalk between melatonin and nitric oxide restrains Cadmium-induced oxidative stress and enhances vinblastine biosynthesis in Catharanthus roseus (L) G Don.Plant cell reports · 2024Article
- Higher Plant-Derived Biostimulants: Mechanisms of Action and Their Role in Mitigating Plant Abiotic Stress.Antioxidants (Basel, Switzerland) · 2024Review
- Functional interaction of melatonin with gasotransmitters and ROS in plant adaptation to abiotic stresses.Frontiers in plant science · 2024Review
- Melatonin Alleviates Antimony Toxicity by Regulating the Antioxidant Response and Reducing Antimony Accumulation inAntioxidants (Basel, Switzerland) · 2023Article
- Article
- Deciphering the melatonin-mediated response and signalling in the regulation of heavy metal stress in plants.Planta · 2023Review
- Phytoremediation as an Effective Remedy for Removing Trace Elements from Ecosystems.Plants (Basel, Switzerland) · 2023Review
- Interactions of melatonin, reactive oxygen species, and nitric oxide during fruit ripening: an update and prospective view.Journal of experimental botany · 2022Review
- Interaction between Melatonin and NO: Action Mechanisms, Main Targets, and Putative Roles of the Emerging Molecule NOmela.International journal of molecular sciences · 2022Review
- How We Can Change Clinical Practice Using Antioxidant Molecules?Antioxidants (Basel, Switzerland) · 2022Article
- Redox post-translational modifications and their interplay in plant abiotic stress tolerance.Frontiers in plant science · 2022Review
- Role of phytomelatonin responsive to metal stresses: An omics perspective and future scenario.Frontiers in plant science · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Metal toxicity in soils, along with water runoff, are increasing environmental problems that affect agriculture directly and, in turn, human health. In light of finding a suitable and urgent solution, research on plant treatments with specific compounds that can help mitigate these effects has increased, and thus the exogenous application of melatonin (MET) and its role in alleviating the negative effects of metal toxicity in plants, have become more important in the last few years. MET is an important plant-related response molecule involved in growth, development, and reproduction, and in the induction of different stress-related key factors in plants. It has been shown that MET plays a protective role against the toxic effects induced by different metals (Pb, Cd, Cu, Zn, B, Al, V, Ni, La, As, and Cr) by regulating both the enzymatic and non-enzymatic antioxidant plant defense systems. In addition, MET interacts with many other signaling molecules, such as reactive oxygen species (ROS) and nitric oxide (NO) and participates in a wide variety of physiological reactions. Furthermore, MET treatment enhances osmoregulation and photosynthetic efficiency, and increases the concentration of other important antioxidants such as phenolic compounds, flavonoids, polyamines (PAs), and carotenoid compounds. Some recent studies have shown that MET appeared to be involved in the regulation of metal transport in plants, and lastly, various studies have confirmed that MET significantly upregulated stress tolerance-related genes. Despite all the knowledge acquired over the years, there is still more to know about how MET is involved in the metal toxicity tolerance of plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.