Evidence map›Paper›PMID 34068174›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Effect of Graphene and Graphene Oxide on Airway Barrier and Differential Phosphorylation of Proteins in Tight and Adherens Junction Pathways.

Sofie Van Den Broucke, Jeroen A J Vanoirbeek, Rita Derua, Peter H M Hoet, Manosij Ghosh

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sofie Van Den BrouckeCentre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium.
Jeroen A J VanoirbeekLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-5508-3518
Rita DeruaLaboratory of Protein Phosphorylation and Proteomics, KU Leuven, 3000 Leuven, Belgium.
Peter H M HoetCentre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-0292-6603
Manosij GhoshCentre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-5034-001X

Funding

Onderzoeksraad, KU Leuven GOA/14/011
6 · The paper itself

Abstract

Via inhalation we are continuously exposed to environmental and occupational irritants which can induce adverse health effects, such as irritant-induced asthma (IIA). The airway epithelium forms the first barrier encountered by these agents. We investigated the effect of environmental and occupational irritants on the airway epithelial barrier in vitro. The airway epithelial barrier was mimicked using a coculture model, consisting of bronchial epithelial cells (16HBE) and monocytes (THP-1) seeded on the apical side of a permeable support, and human lung microvascular endothelial cells (HLMVEC) grown on the basal side. Upon exposure to graphene (G) and graphene oxide (GO) in a suspension with fetal calf serum (FCS), ammonium persulfate (AP), sodium persulfate (SP) and hypochlorite (ClO

Indexed as

adherens junctionbarrier integritygraphene nanoparticlesphosphoproteomicstight junction

Identifiers

PMID34068174
PMCPMC8152977

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.