ArticleMaterials (Basel, Switzerland)2021
Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments.
Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Physical and Chemical Properties of All-in-One Root Canal Irrigants: A Laboratory Study.European journal of dentistry · 2026Article
- Effect of Novel All-in-One Root Canal Irrigants on Dislodgement Resistance of Epoxy Resin and Hydraulic Calcium Silicate Sealers: An Ex vivo Study.European journal of dentistry · 2026Article
- Dissolution versus dislodgment of dentin debris by pulsed erbium-doped yttrium aluminum garnet laser-activated endodontic irrigants.Lasers in medical science · 2026Article
- The Mechanical Footprint of Dual Rinse 1-Hydroxyethane 1,1-Diphosphonate on Fast-Set Mineral Trioxide Aggregate Microhardness and Dislocation Resistance.TheScientificWorldJournal · 2026Article
- Effect of EDTA, NaOCl, and HEDP-based irrigants on the mechanical properties of heat treated NiTi endodontic instruments.BDJ open · 2025Article
- Evaluating the interaction of local anesthetic agents with sequential and continuous chelation in root dentin - AnJournal of conservative dentistry and endodontics · 2025Article
- Root canal irrigants effect on the compressive strength and calcium ion release of Biodentine.Heliyon · 2024Article
- Effect of sodium hypochlorite, ethylenediaminetetraacetic acid, and dual-rinse irrigation on dentin adhesion using an etch-and-rinse or self-etch approach.Scientific reports · 2024Article
- 2D and 3D Erosion Landscape Analysis of Endodontic-Treated Teeth Using EDTA and HEDP as Chelating Agents: A High-Resolution Micro-Computed Tomographic Study.Dentistry journal · 2023Article
- Impact of Final Irrigation Protocol on the Push-Out Bond Strength of Two Types of Endodontic Sealers.Materials (Basel, Switzerland) · 2023Article
- A critical analysis of research methods and experimental models to study irrigants and irrigation systems.International endodontic journal · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The addition of Dual Rinse HEDP, an etidronate powder, to a sodium hypochlorite (NaOCl) solution can create a combined single endodontic irrigant with a soft tissue-dissolving and a decalcifying effect, which can replace traditional alternating irrigation with chemically non-compatible solutions. While the short-term compatibility between NaOCl and 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) has been shown, it remains unclear whether ultrasonic activation of a combined NaOCl & HEDP solution immediately reduces the available chlorine and/or renders the NaOCl ineffective in dissolving organic tissue remnants. This was tested in three experiments: (1) direct activation in test tubes in an ultrasonic bath and then the activation by an ultrasonically oscillating tip (IrriSafe) in (2) an epoxy resin model containing a simulated isthmus filled with gelatin, and (3) extracted teeth with simulated resorption cavities filled with soft tissue. The control solutions were physiological saline and 2.5% NaOCl without HEDP. In (1), available chlorine after 30 s of ultrasonic activation (37 kHz) of test and control solution was assessed, as well as shrimp tissue weight loss in direct exposure. In (2) and (3), the ultrasonic tip was driven at 1/3 of full power using the respective unit, and areas of removed gelatin from the isthmus and tissue weight loss were used as the outcomes, respectively. Experiment (1) revealed no negative impact by HEDP on available chlorine (1), while all three experiments showed a highly significant (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.