Evidence map›Paper›PMID 34068071›Full record

ArticleJournal of clinical medicine2021

Clinical Relevance of Torque Teno Virus (TTV) in HIV/HCV Coinfected and HCV Monoinfected Patients Treated with Direct-Acting Antiviral Therapy.

Daniele Lapa, Paola Del Porto, Claudia Minosse, Gianpiero D'Offizi, Andrea Antinori, Maria Rosaria Capobianchi, Ubaldo Visco-Comandini, Fiona McPhee, Anna Rosa Garbuglia, Mauro Zaccarelli

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Review
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  7. Article
  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Daniele LapaLaboratory of Virology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, IRCCS, 00149 Rome, Italy.
Paola Del PortoDepartment of Biology and Biotechnology "C. Darwin", Sapienza University, 00185 Rome, Italy.
Claudia MinosseLaboratory of Virology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7833-9539
Gianpiero D'OffiziHepatology and Infectious Diseases Unit, "Lazzaro Spallanzani" National Institute for Infectious Diseases IRCCS, 00149 Rome, Italy.
Andrea AntinoriClinical Department, "Lazzaro Spallanzani " National Institute for Infectious Diseases, IRCCS, 00149 Rome, Italy.
Maria Rosaria CapobianchiLaboratory of Virology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, IRCCS, 00149 Rome, Italy.
Ubaldo Visco-ComandiniHepatology and Infectious Diseases Unit, "Lazzaro Spallanzani" National Institute for Infectious Diseases IRCCS, 00149 Rome, Italy.
Fiona McPheeBristol-Myers Squibb, Cambridge, MA 02142, USA.
Anna Rosa GarbugliaLaboratory of Virology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, IRCCS, 00149 Rome, Italy.ORCID 0000-0002-2687-8642
Mauro ZaccarelliClinical Department, "Lazzaro Spallanzani " National Institute for Infectious Diseases, IRCCS, 00149 Rome, Italy.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITBristol-Myers Squibb (United States) · USSapienza University of Rome · IT

Funding

Ministero della Salute Ricerca corrente , linea 3
6 · The paper itself

Abstract

Torque Teno virus (TTV) is a ubiquitous virus that causes chronic infection in humans with unknown clinical consequences. Here, we investigated the influence of TTV infection on HCV direct-acting antiviral (DAA) efficacy in HIV/HCV coinfected and HCV monoinfected patients as controls. Of 92 study patients, 79.3% were TTV DNA positive; untreated patients exhibited a significantly higher proportion of TTV DNA-positivity vs. sustained virological response (SVR) patients (100.0% vs. 65.2%,

Indexed as

cytokinesDAA therapyHepatitis C virusHIV/HCV coinfectionTorque Teno virus (TTV)

Identifiers

PMID34068071
PMCPMC8152458
OpenAlexW3162766575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.