Evidence map›Paper›PMID 34067989›Full record

ReviewInternational journal of molecular sciences2021

The Design of Abnormal Microenvironment Responsive MRI Nanoprobe and Its Application.

Ancong Wang, Xiao Han, Wenliu Qi, Sihui Du, Zhenqi Jiang, Xiaoying Tang

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Molecular Imaging in Nanomedical Research 2.0.International journal of molecular sciences · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ancong WangSchool of Life Science, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China.ORCID 0000-0002-1418-4694
Xiao HanSchool of Life Science, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China.
Wenliu QiSchool of Life Science, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China.
Sihui DuSchool of Life Science, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China.
Zhenqi JiangSchool of Life Science, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China.ORCID 0000-0002-2685-1327
Xiaoying TangSchool of Life Science, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China.
Beijing Institute of Technology · CN

Funding

China Postdoctoral Science Foundation 2020M680395National Key R&D Program of China 2020YFC2007301, 2020YFC2007300National Natural Science Foundation of China 82072009
6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) is often used to diagnose diseases due to its high spatial, temporal and soft tissue resolution. Frequently, probes or contrast agents are used to enhance the contrast in MRI to improve diagnostic accuracy. With the development of molecular imaging techniques, molecular MRI can be used to obtain 3D anatomical structure, physiology, pathology, and other relevant information regarding the lesion, which can provide an important reference for the accurate diagnosis and treatment of the disease in the early stages. Among existing contrast agents, smart or activatable nanoprobes can respond to selective stimuli, such as proving the presence of acidic pH, active enzymes, or reducing environments. The recently developed environment-responsive or smart MRI nanoprobes can specifically target cells based on differences in the cellular environment and improve the contrast between diseased tissues and normal tissues. Here, we review the design and application of these environment-responsive MRI nanoprobes.

Indexed as

Contrast MediaHumansMagnetic Resonance ImagingMagnetite NanoparticlesMolecular ProbesContrast MediaMagnetite NanoparticlesMolecular Probesapplicationdesignenvironment responsiveMRI nanoprobe

Identifiers

PMID34067989
PMCPMC8152268
OpenAlexW3160100344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.