Evidence map›Paper›PMID 34067822›Full record

ArticleInfectious disease reports2021

Remdesivir Treatment for COVID 19 in Pregnant Patients with Moderate to Severe Symptoms: Serial Case Report.

Yudianto Budi Saroyo, Amanda Rumondang, Irene Sinta Febriana, Achmad Kemal Harzif, Rima Irwinda

Open access · goldAbstract readCase Reports
In one paragraph

Article in Infectious disease reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Management of Coronavirus Disease-2019 Infection in Pregnancy.Emergency medicine clinics of North America · 2023
    Review
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yudianto Budi SaroyoObstetric Gynecology Department, Maternal Fetal Medicine Division, Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia.
Amanda RumondangObstetric Gynecology Department, Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia.ORCID 0000-0002-7949-4415
Irene Sinta FebrianaObstetric Gynecology Department, Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia.
Achmad Kemal HarzifReproductive Endocrinology and Infertility Division, Obstetric Gynecology Department, Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia.ORCID 0000-0002-3552-1610
Rima IrwindaObstetric Gynecology Department, Maternal Fetal Medicine Division, Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia.ORCID 0000-0002-6260-6273
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSevere Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infection that causes CASE ILLUSTRATION: We briefly describe five serial cases being treated with Remdesivir therapy during hospitalization. Four cases were delivered by cesarean section, and one was delivered vaginally in gestation week 37. All cases showed a shortened duration of hospitalization, rapid improvement in clinical symptoms, and no adverse events were observed in mothers, fetuses, and neonates. DISCUSSION: Remdesivir, an inhibitor RNA Polymerase, has been used in COVID-19 treatment and is known to shorten recovery time in nonpregnant women. Some studies have shown no adverse effects on Remdesivir for pregnant women. Based on randomized control trial (RCT) during the Ebola epidemic, Remdesivir was safe to use for pregnant women. All cases showed reduced hospitalization time and better clinical outcomes without maternal, fetal, or neonatal adverse events.

conclusionRemdesivir protocol for pregnant women with moderate to severe symptoms of COVID-19 has resulted in better clinical improvement with a shorter recovery period and no adverse effects during the hospitalization period. Further studies and RCT are warranted to evaluate the biosafety and effects of Remdesivir in pregnant women.

Indexed as

COVID-19moderate–severe symptomspregnancyRemdesivir

Identifiers

PMID34067822
PMCPMC8162322
OpenAlexW3163681151

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.