Evidence map›Paper›PMID 34067745›Full record

ArticleViruses2021

An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.

Pragya D Yadav, Dimpal A Nyayanit, Triparna Majumdar, Savita Patil, Harmanmeet Kaur, Nivedita Gupta, Anita M Shete, Priyanka Pandit, Abhinendra Kumar, Neeraj Aggarwal and 38 more

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Delta variant SARS-CoV-2 infections in pediatric cases during the second wave in India.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2022
    Article
  11. Article
  12. Article
  13. Evolution of the SARS-CoV-2 pandemic in India.Medical journal, Armed Forces India · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Pragya D YadavIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.ORCID 0000-0002-0861-7166
Dimpal A NyayanitIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.
Triparna MajumdarIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.
Savita PatilIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.
Harmanmeet KaurIndian Council of Medical Research, New Delhi 110029, India.
Nivedita GuptaIndian Council of Medical Research, New Delhi 110029, India.
Anita M SheteIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.
Priyanka PanditIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.ORCID 0000-0003-4845-2172
Abhinendra KumarIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.
Neeraj AggarwalIndian Council of Medical Research, New Delhi 110029, India.ORCID 0000-0003-3139-2994
Jitendra NarayanIndian Council of Medical Research, New Delhi 110029, India.ORCID 0000-0002-3797-9086
Neetu VijayIndian Council of Medical Research, New Delhi 110029, India.
Usha KalawatSri Venkateswara Institute of Medical Sciences, Tirupati 517507, India.
Attayur P SugunanICMR-NIV Field Unit, Kerala 688005, India.
Ashok MunivenkatappaICMR-NIV, Bangalore Unit, Bangalore 560029, India.
Tara SharmaVRDL Sikkim Government College of Nursing, Gangtok 737101, India.
Sulochna DeviRegional Institute of Medical Sciences IMPHAL, Imphal 795004, India.
Tapan MajumdarGovernment Medical College, Agartala, Tripura 799006, India.
Subhash JaryalDr. Rajendra Prasad Government Medical College, (H.P.), Kangra 176001, India.
Rupinder BakshiGovernment Medical College, Patiala 147001, India.
Yash JoshiIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.ORCID 0000-0002-6626-1137
Rima SahayIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.
Jayanti ShastriKasturba Hospital for Infectious Diseases, Mumbai 400034, India.
Mini SinghPost Graduate Institute of Medical Education & Research, Chandigarh 160012, India.
Manoj KumarRajendra Institute of Medical Sciences, Ranchi 834009, India.ORCID 0000-0003-2740-2512
Vinita RawatGovernment Medical College, Haldwani 263129, India.
Shanta DuttaNational Institute of Cholera and Enteric Diseases, Kolkata 700010, India.ORCID 0000-0002-6897-7390
Sarita YadavBhagat Phool Singh Government Medical College, Sonipat 131305, India.
Kaveri KrishnasamyKing Institute of Preventive Medicine & Research, Chennai 600032, India.
Sharmila RautIndira Gandhi Government Medical College & Hospital, Nagpur 440018, India.
Debasis BiswasAll India Institute of Medical Sciences, Bhopal 462020, India.
Biswajyoti BorkakotyRegional Medical Research Centre, Dibrugarh 786010, India.
Santwana VermaIndira Gandhi Medical College & Hospital, Shimla 171001, India.
Sudha RaniOsmania Medical College, Hyderabad 500095, India.
Hirawati DevalRegional Medical Research Center Gorakhpur, Gorakhpur 273013, India.
Disha PatelB.J. Medical College, Ahmedabad 380016, India.
Jyotirmayee TurukRMRC, Bhubaneswar 751023, India.
Bharti MalhotraSawai Man Singh Medical College, Jaipur 302004, India.
Bashir FomdaSher-I-Kashmir Institute of Medical Sciences, Srinagar 190011, India.
Vijaylakshmi NagAll India Institute of Medical Sciences, Jodhpur 342005, India.
Amita JainDepartment of Microbiology, King George's Medical University, Lucknow 226003, India.
Anudita BhargavaAll India Institute of Medical Sciences, Raipur, Raipur 492099, India.
Varsha PotdarIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.ORCID 0000-0002-7535-7878
Sarah CherianIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.
Priya AbrahamIndian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune 411021, India.
Anjani GopalIndian Institute of Science Education and Research, Pune 411008, India.
Samiran PandaIndian Council of Medical Research, New Delhi 110029, India.ORCID 0000-0002-5077-6275
Balram BhargavaIndian Council of Medical Research, New Delhi 110029, India.

Funding

ICMR-National Institute of Virology 20-3-18N
6 · The paper itself

Abstract

The number of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) cases is increasing in India. This study looks upon the geographic distribution of the virus clades and variants circulating in different parts of India between January and August 2020. The NPS/OPS from representative positive cases from different states and union territories in India were collected every month through the VRDLs in the country and analyzed using next-generation sequencing. Epidemiological analysis of the 689 SARS-CoV-2 clinical samples revealed GH and GR to be the predominant clades circulating in different states in India. The northern part of India largely reported the 'GH' clade, whereas the southern part reported the 'GR', with a few exceptions. These sequences also revealed the presence of single independent mutations-E484Q and N440K-from Maharashtra (first observed in March 2020) and Southern Indian States (first observed in May 2020), respectively. Furthermore, this study indicates that the SARS-CoV-2 variant (VOC, VUI, variant of high consequence and double mutant) was not observed during the early phase of virus transmission (January-August). This increased number of variations observed within a short timeframe across the globe suggests virus evolution, which can be a step towards enhanced host adaptation.

Indexed as

AdultCOVID-19FemaleGenome, ViralGenomicsHigh-Throughput Nucleotide SequencingHumansIndiaMaleMiddle AgedMutationPhylogenyPhylogeographySARS-CoV-2cladesepidemiologyIndiaNGSSARS-CoV-2

Identifiers

PMID34067745
PMCPMC8156686

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