Evidence map›Paper›PMID 34067678›Full record

ArticleMolecules (Basel, Switzerland)2021

Ergosta-7,9(11),22-trien-3β-ol Alleviates Intracerebral Hemorrhage-Induced Brain Injury and BV-2 Microglial Activation.

Po-Jen Hsueh, Mong-Heng Wang, Che-Jen Hsiao, Chih-Kuang Chen, Fan-Li Lin, Shu-Hsien Huang, Jing-Lun Yen, Ping-Huei Tsai, Yueh-Hsiung Kuo, George Hsiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Po-Jen HsuehGraduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Mong-Heng WangDepartment of Physiology, Medical College of Georgia, Augusta University, GA 30912, USA.
Che-Jen HsiaoGraduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chih-Kuang ChenGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Fan-Li LinMenzies Institute for Medical Research, University of Tasmania, Hobart 7000, Tasmania, Australia.
Shu-Hsien HuangGraduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Jing-Lun YenGraduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Ping-Huei TsaiTranslational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Yueh-Hsiung KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan.
George HsiaoGraduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-9079-3646
Taipei Medical University · TWAsia University · TWAugusta University · USChang Gung University · TWChina Medical University · TWUniversity of Tasmania · AU

Funding

China Medical University grant in Taiwan 10959189 and CMU109-AWARD-02"Chinese Medicine Research Center, China Medical University" from The Featured Areas Re-search Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan CMRC-CHM-2-1Ministry of Science and Technology in Taiwan MOST107-2320-B-038-025-MY3National Science Council in Taiwan NSC99-2320-B-001-MY3 and NSC102-2628-B-038-009-MY3
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is a devastating neurological disorder characterized by an exacerbation of neuroinflammation and neuronal injury, for which few effective therapies are available at present. Inhibition of excessive neuroglial activation has been reported to alleviate ICH-related brain injuries. In the present study, the anti-ICH activity and microglial mechanism of ergosta-7,9(11),22-trien-3β-ol (EK100), a bioactive ingredient from Asian medicinal herb

Indexed as

AnimalsBrainBrain InjuriesCerebral HemorrhageCyclooxygenase 2ErgosterolJNK Mitogen-Activated Protein KinasesMacrophage ActivationMacrophagesMaleMAP Kinase Signaling SystemMatrix Metalloproteinase 9MiceMice, Inbred C57BLMicrogliaPolyporalesCyclooxygenase 2ErgosterolJNK Mitogen-Activated Protein KinasesMatrix Metalloproteinase 9COX-2ergosta-7,9(11),22-trien-3β-olintracerebral hemorrhageJNKmicrogliaMMP-9

Identifiers

PMID34067678
PMCPMC8156058
OpenAlexW3162238187

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.