Evidence map›Paper›PMID 34067632›Full record

ReviewNutrients2021

Coenzyme Q

Lara Testai, Alma Martelli, Lorenzo Flori, Arrigo F G Cicero, Alessandro Colletti

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05128292 (Role of the NLRP3 Inflammasome Activation, Mitochondrial Biogenesis, and Immunoinflammatory Response After Oral Coenzyme Q10 Plus Selenium Supplementation in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome), which is not on this map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05128292 nacompletednot on this map

Role of the NLRP3 Inflammasome Activation, Mitochondrial Biogenesis, and Immunoinflammatory Response After Oral Coenzyme Q10 Plus Selenium Supplementation in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

TypeinterventionalSponsorHospital Universitari Vall d'Hebron Research InstituteRan2018 to 2018Enrolled42ConditionsMyalgic EncephalomyelitisArmsCoQ10 plus Selenium
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Coenzyme QNutrients · 2022
    Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Optimized CoQ10 deliveryRSC advances · 2026
    Article
  9. Review
  10. BPM31510 Increases the CoQ Pool in Chemically Induced CoQ-Deficient Cells, CoQ-Deficient Patient Fibroblasts, and in Metabolically Active Murine Tissues.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  11. Review
  12. Article
  13. The Role of Mitochondrial Complexes in Liver Diseases.Journal of clinical and translational hepatology · 2025
    Review
  14. Detection ofAntioxidants (Basel, Switzerland) · 2025
    Article
  15. Review
  16. Diabetes Risks of Statin Therapy-Coenzyme Q10 May Help.Reviews in cardiovascular medicine · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lara TestaiDepartment of Pharmacy, University of Pisa, 56120 Pisa, Italy.ORCID 0000-0003-2431-6248
Alma MartelliDepartment of Pharmacy, University of Pisa, 56120 Pisa, Italy.ORCID 0000-0002-2090-7107
Lorenzo FloriDepartment of Pharmacy, University of Pisa, 56120 Pisa, Italy.
Arrigo F G CiceroMedical and Surgical Sciences Department, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-4367-3884
Alessandro CollettiItalian Nutraceutical Society (SINut), 40138 Bologna, Italy.
University of Pisa · ITUniversity of Bologna · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coenzyme Q

Indexed as

Dietary SupplementsBiological AvailabilityHumansMigraine DisordersNeoplasmsNeurodegenerative DiseasesNeuromuscular DiseasesQuality of LifeUbiquinonecoenzyme Q10Ubiquinonecancercoenzyme Q10neuronal and muscular degenerative disorderspreventionsupplementationubiquinone

Identifiers

PMID34067632
PMCPMC8156424
OpenAlexW3161938506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.