Evidence map›Paper›PMID 34067622›Full record

ReviewNutrients2021

Iron Deficiency Anemia in Celiac Disease.

Valentina Talarico, Laura Giancotti, Giuseppe Antonio Mazza, Roberto Miniero, Marco Bertini

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
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  5. Observational
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  19. The formation of FeJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Valentina TalaricoDepartment of Pediatric, Pugliese-Ciaccio Hospital, 88100 Catanzaro, Italy.ORCID 0000-0001-9027-6921
Laura GiancottiUnit of Pediatrics, University "Magna Graecia", 88100 Catanzaro, Italy.
Giuseppe Antonio MazzaDepartment of Pediatric Cardiology, Regina Margherita Hospital, Città della Salute e della Scienza, 10126 Torino, Italy.
Roberto MinieroDepartment of Pediatric, Pugliese-Ciaccio Hospital, 88100 Catanzaro, Italy.
Marco BertiniR&D Department, Laboratori Baldacci SpA, 56121 Pisa, Italy.ORCID 0000-0003-1469-7825
Azienda Ospedaliera Pugliese Ciaccio · ITBaldacci (Italy) · ITMagna Graecia University · ITOspedale Regina Margherita · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The iron absorption process developsmainly in the proximal duodenum. This portion of the intestine is typically destroyed in celiac disease (CD), resulting in a reduction in absorption of iron and subsequent iron deficiency anemia (IDA). In fact, the most frequent extra-intestinal manifestation (EIM) of CD is IDA, with a prevalence between 12 and 82% (in relation with the various reports) in patients with new CD diagnosis. The primary treatment of CD is the gluten-free diet (GFD), which is associated with adequate management of IDA, if present. Iron replacement treatment historically has been based on oral products containing ferrous sulphate (FS). However, the absorption of FS is limited in patients with active CD and unpredictable in patients on a GFD. Furthermore, a poor tolerability of this kind of ferrous is particularly frequent in patients with CD or with other inflammatory bowel diseases. Normalization from anemic state typically occurs after at least 6 months of GFD, but the process can take up to 2 years for iron stores to replenish.

Indexed as

Diet, Gluten-FreeIron DeficienciesAnemia, Iron-DeficiencyCeliac DiseaseDuodenumHumansIntestinal AbsorptionIronIronCeliac diseaseiron absorptionIron deficiency Anemia

Identifiers

PMID34067622
PMCPMC8156426
OpenAlexW3163208621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.