Evidence map›Paper›PMID 34067579›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Bacterial Resistance to Antimicrobial Agents.

Manuel F Varela, Jerusha Stephen, Manjusha Lekshmi, Manisha Ojha, Nicholas Wenzel, Leslie M Sanford, Alberto J Hernandez, Ammini Parvathi, Sanath H Kumar

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 267 citations in OpenAlex.

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  9. Myconanotechnology: evaluation of Ag-Cu bimetallic nanoparticles synthesized by Ganoderma aff. australe against pathogens and cancer cells.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Manuel F VarelaDepartment of Biology, Eastern New Mexico University, Portales, NM 88130, USA.ORCID 0000-0001-8667-7853
Jerusha StephenPost-Harvest Technology, ICAR-Central Institute of Fisheries Education, Seven Bungalows, Andheri (W), Mumbai 400061, India.ORCID 0000-0001-9434-3140
Manjusha LekshmiPost-Harvest Technology, ICAR-Central Institute of Fisheries Education, Seven Bungalows, Andheri (W), Mumbai 400061, India.
Manisha OjhaDepartment of Biology, Eastern New Mexico University, Portales, NM 88130, USA.
Nicholas WenzelDepartment of Biology, Eastern New Mexico University, Portales, NM 88130, USA.
Leslie M SanfordDepartment of Biology, Eastern New Mexico University, Portales, NM 88130, USA.
Alberto J HernandezDepartment of Biology, Eastern New Mexico University, Portales, NM 88130, USA.
Ammini ParvathiCSIR-National Institute of Oceanography, Regional Centre, Kochi 682018, India.ORCID 0000-0001-6916-2671
Sanath H KumarPost-Harvest Technology, ICAR-Central Institute of Fisheries Education, Seven Bungalows, Andheri (W), Mumbai 400061, India.ORCID 0000-0003-0223-9069
Eastern New Mexico University · USCentral Institute of Fisheries Education · INNational Institute of Oceanography · IN

Funding

NM-INBRE Sequencing and Bioinformatics CoreP20GM103451 · NIGMS · NEW MEXICO STATE UNIVERSITY LAS CRUCES · PI Charlotte C. Gard · 2012 to 2026
$61.2M
NIGMS NIH HHS P20 GM103451
6 · The paper itself

Abstract

Bacterial pathogens as causative agents of infection constitute an alarming concern in the public health sector. In particular, bacteria with resistance to multiple antimicrobial agents can confound chemotherapeutic efficacy towards infectious diseases. Multidrug-resistant bacteria harbor various molecular and cellular mechanisms for antimicrobial resistance. These antimicrobial resistance mechanisms include active antimicrobial efflux, reduced drug entry into cells of pathogens, enzymatic metabolism of antimicrobial agents to inactive products, biofilm formation, altered drug targets, and protection of antimicrobial targets. These microbial systems represent suitable focuses for investigation to establish the means for their circumvention and to reestablish therapeutic effectiveness. This review briefly summarizes the various antimicrobial resistance mechanisms that are harbored within infectious bacteria.

Indexed as

antimicrobial resistancebacteriainfectionmultidrug resistancepathogenesis

Identifiers

PMID34067579
PMCPMC8157006
OpenAlexW3162929884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.