Evidence map›Paper›PMID 34067575›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Sudden Death without a Clear Cause after Comprehensive Investigation: An Example of Forensic Approach to Atypical/Uncertain Findings.

Simone Grassi, Mònica Coll Vidal, Oscar Campuzano, Vincenzo Arena, Alessandro Alfonsetti, Sabina Strano Rossi, Francesca Scarnicci, Anna Iglesias, Ramon Brugada, Antonio Oliva

Open access · goldAbstract readCase Reports
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Review
  6. Brugada syndrome in the forensic field: what do we know to date?Frontiers in cardiovascular medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Simone GrassiSection of Legal Medicine, Department of Health Surveillance and Bioethics, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-2420-6658
Mònica Coll VidalCardiovascular Genetics Center, University of Girona-IDIBGI, 17290 Salt, Girona, Spain.
Oscar CampuzanoCardiovascular Genetics Center, University of Girona-IDIBGI, 17290 Salt, Girona, Spain.ORCID 0000-0001-5298-5276
Vincenzo ArenaInstitute of Anatomical Pathology, Department of Woman and Child Health and Public Health, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Alessandro AlfonsettiSection of Legal Medicine, Department of Health Surveillance and Bioethics, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Sabina Strano RossiSection of Legal Medicine, Department of Health Surveillance and Bioethics, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Francesca ScarnicciSection of Legal Medicine, Department of Health Surveillance and Bioethics, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Anna IglesiasCardiovascular Genetics Center, University of Girona-IDIBGI, 17290 Salt, Girona, Spain.
Ramon BrugadaCardiovascular Genetics Center, University of Girona-IDIBGI, 17290 Salt, Girona, Spain.
Antonio OlivaSection of Legal Medicine, Department of Health Surveillance and Bioethics, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0001-7112-9096
Università Cattolica del Sacro Cuore · ITUniversitat de Girona · ES

Funding

Università Cattolica del Sacro Cuore Linea D3.1
6 · The paper itself

Abstract

Sudden death (SD) is defined as the unexpected natural death occurred within an hour after the onset of symptoms or from the last moment the subject has been seen in a healthy condition. Brugada syndrome (BrS) is one of the most remarkable cardiac causes of SD among young people. We report the case of a 20-year-old man who suddenly died after reportedly having smoked cannabis. Autopsy, toxicology, and genetic testing were performed. Autopsy found a long and thick myocardial bridging (MB) at 2 cm from the beginning of the left anterior descending coronary artery. Furthermore, at the histopathological examination, fibrosis and disarray in myocardial area above the MB, fatty tissue in the right ventricle and fibrosis of the sino-atrial node area were found. Toxicology testing was inconclusive, while genetic testing found a rare missense variant of the

Indexed as

Brugada syndromecannabisfatty infiltration right ventricleforensic pathologymolecular autopsymyocardial bridgingsino-atrial node fibrosisSLMAP genesudden deathTTN gene

Identifiers

PMID34067575
PMCPMC8156818
OpenAlexW3162691242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.