Evidence map›Paper›PMID 34067569›Full record

ArticlePolymers2021

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine.

Esam Bashir Yahya, A A Amirul, Abdul Khalil H P S, Niyi Gideon Olaiya, Muhammad Omer Iqbal, Fauziah Jummaat, Atty Sofea A K, A S Adnan

Abstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Starch-Based Scaffolds for Cultivated Meat Production: Challenges and Perspectives.Comprehensive reviews in food science and food safety · 2025
    Review
  3. Review
  4. Data-Driven Review on Aerogels and Polymeric Aerogels.Angewandte Chemie (International ed. in English) · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Market of tissue engineering in Canada from 2011 to 2020.Frontiers in bioengineering and biotechnology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Esam Bashir YahyaSchool of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia.ORCID 0000-0002-1599-1754
A A AmirulSchool of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.ORCID 0000-0002-5014-1472
Abdul Khalil H P SSchool of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia.ORCID 0000-0003-2403-809X
Niyi Gideon OlaiyaDepartment of Industrial and Production Engineering, Federal University of Technology, PMB 704 Akure, Nigeria.ORCID 0000-0002-2695-705X
Muhammad Omer IqbalShandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.ORCID 0000-0002-7122-9422
Fauziah JummaatManagement & Science University Medical Centre, University Drive, Off Persiaran Olahraga, Section 13, Shah Alam 40100, Malaysia.
Atty Sofea A KHospital Seberang Jaya, Jalan Tun Hussein Onn, Seberang Jaya, Permatang Pauh 13700, Malaysia.
A S AdnanManagement & Science University Medical Centre, University Drive, Off Persiaran Olahraga, Section 13, Shah Alam 40100, Malaysia.

Funding

Universiti Sains Malaysia RUI 1001 / PTEKIND / 8014119
6 · The paper itself

Abstract

The global transplantation market size was valued at USD 8.4 billion in 2020 and is expected to grow at a compound annual growth rate of 11.5% over the forecast period. The increasing demand for tissue transplantation has inspired researchers to find alternative approaches for making artificial tissues and organs function. The unique physicochemical and biological properties of biopolymers and the attractive structural characteristics of aerogels such as extremely high porosity, ultra low-density, and high surface area make combining these materials of great interest in tissue scaffolding and regenerative medicine applications. Numerous biopolymer aerogel scaffolds have been used to regenerate skin, cartilage, bone, and even heart valves and blood vessels by growing desired cells together with the growth factor in tissue engineering scaffolds. This review focuses on the principle of tissue engineering and regenerative medicine and the role of biopolymer aerogel scaffolds in this field, going through the properties and the desirable characteristics of biopolymers and biopolymer tissue scaffolds in tissue engineering applications. The recent advances of using biopolymer aerogel scaffolds in the regeneration of skin, cartilage, bone, and heart valves are also discussed in the present review. Finally, we highlight the main challenges of biopolymer-based scaffolds and the prospects of using these materials in regenerative medicine.

Indexed as

aerogelsbiocompatibilitybiopolymersregenerative medicinescaffoldtissue engineering

Identifiers

PMID34067569
PMCPMC8156123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.