ArticleDiagnostics (Basel, Switzerland)2021
Elevation of CD40/CD40L Inflammatory Pathway Molecules in Carotid Plaques from Moderate-and-Severe Obstructive Sleep Apnea Patients.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Expression of Inflammatory Markers in Ascending Thoracic Aorta in Patients with Obstructive Sleep Apnea.International journal of molecular sciences · 2026Article
- Obstructive Sleep Apnea in Patients with Significant Coronary Artery Disease: An Underdiagnosed Condition.Journal of clinical medicine · 2026Article
- A pilot study on the effect of severe sleep fragmentation on aorta remodelling, neuroinflammation in a rat model.Scientific reports · 2025Article
- Association of estimated pulse wave velocity with all-cause mortality and cardiovascular mortality in obstructive sleep apnea patients: results from NHANES.Frontiers in cardiovascular medicine · 2025Article
- Machine learning methods for adult OSAHS risk prediction.BMC health services research · 2024Article
- Markers of Carotid Plaque Destabilization in Patients With Sleep-Disordered Breathing.Frontiers in neurology · 2022Article
- Association Cystatin C and Risk of Stroke in Elderly Patients With Obstructive Sleep Apnea: A Prospective Cohort Study.Frontiers in neuroscience · 2021Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
A chronic inflammatory process characteristic of obstructive sleep apnea promotes vascular endothelial dysfunction and atherogenesis. This process can lead to destabilization and rupture of cardiovascular plaques, which clinically manifests as an acute coronary syndrome or stroke. The aim of this study was to investigate the inflammatory pathway leading to plaque destabilization in non-to-mild and moderate-to-severe groups of OSA patients. This prospective study involved enrollment of patients scheduled for endarterectomy. A sleep study was performed prior to surgery. Immunohistochemistry was performed on atherosclerotic plaques from carotid arteries obtained during standard open endarterectomy to determine levels of CD40, CD40L receptors, MCP-1, and MMP-9. The 46 patients included 14 controls, 13 with mild, 11 with moderate, and 8 with severe OSA. Increased expression of CD40, CD40L receptors, MCP-1, and MMP-9 were found to be proportionate with OSA severity. However, significant differences among groups were observed only for MCP-1 (
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