Evidence map›Paper›PMID 34067471›Full record

ReviewAntibiotics (Basel, Switzerland)2021

An Overview of Antimicrobial Compounds from African Edible Insects and Their Associated Microbiota.

Cynthia M Mudalungu, Chrysantus M Tanga, Segenet Kelemu, Baldwyn Torto

Abstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
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  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cynthia M MudalunguInternational Centre of Insect Physiology and Ecology (icipe), P.O. Box 30772, Nairobi GPO-00100, Kenya.ORCID 0000-0002-2111-3974
Chrysantus M TangaInternational Centre of Insect Physiology and Ecology (icipe), P.O. Box 30772, Nairobi GPO-00100, Kenya.ORCID 0000-0002-5788-7920
Segenet KelemuInternational Centre of Insect Physiology and Ecology (icipe), P.O. Box 30772, Nairobi GPO-00100, Kenya.
Baldwyn TortoInternational Centre of Insect Physiology and Ecology (icipe), P.O. Box 30772, Nairobi GPO-00100, Kenya.

Funding

Bioinnovate Africa Programme INSBIZ-Contribution ID No. 51050076Canadian International Development Research Centre (IDRC) and the Australian Centre for In-ternational Agricultural Research (ACIAR) INSFEED - Phase 2: Cultivate Grant No: 108866-001Norwegian Agency for Development Cooperation, the Section for research, innovation, and higher education RAF-3058 KEN-18/0005 (CAP-Africa)Rockefeller Foundation (SiPFeed) 2018 FOD 009the Netherlands Organization for Scientific Research, WOTRO Science for Global Development (NWO-WOTRO) ILIPA - W 08.250.202
6 · The paper itself

Abstract

The need for easily biodegradable and less toxic chemicals in drug development and pest control continues to fuel the exploration and discovery of new natural molecules. Like certain plants, some insects can also respond rapidly to microbial infections by producing a plethora of immune-induced molecules that include antibacterial and antifungal peptides/polypeptides (AMPs), among other structurally diverse small molecules. The recent recognition that new natural product-derived scaffolds are urgently needed to tackle life-threatening pathogenic infections has been prompted by the health threats posed by multidrug resistance. Although many researchers have concentrated on the discovery of AMPs, surprisingly, edible insect-produced AMPs/small molecules have received little attention. This review will discuss the recent advances in the identification and bioactivity analysis of insect AMPs, with a focus on small molecules associated with the microbiota of selected African edible insects. These molecules could be used as templates for developing next-generation drugs to combat multidrug-resistant pathogens.

Indexed as

antimicrobial peptidesedible insectsgutmicrobiotamultidrug resistancesmall molecules

Identifiers

PMID34067471
PMCPMC8224635

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.