Evidence map›Paper›PMID 34067440›Full record

ArticleInternational journal of molecular sciences2021

miR155 Deficiency Reduces Myofibroblast Density but Fails to Improve Cardiac Function after Myocardial Infarction in Dyslipidemic Mouse Model.

David Schumacher, Adelina Curaj, Sakine Simsekyilmaz, Andreas Schober, Elisa A Liehn, Sebastian F Mause

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. The Role of ncRNAs in Cardiac Infarction and Regeneration.Journal of cardiovascular development and disease · 2023
    Review
  4. Noncoding RNAs and Cardiac Fibrosis.Reviews in cardiovascular medicine · 2023
    Review
  5. Review
  6. Article
  7. Molecular Research in Cardiovascular Disease.International journal of molecular sciences · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

David SchumacherInstitute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-2308-6543
Adelina CurajInstitute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Sakine SimsekyilmazInstitute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Andreas SchoberInstitute for Prevention and Epidemiology of Cardiovascular Disease, University of Munich, 80539 München, Germany.
Elisa A LiehnInstitute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-1253-3272
Sebastian F MauseDepartment of Cardiology, Pulmonology, Angiology and Intensive Care, University Hospital, RWTH Aachen University, 52074 Aachen, Germany.
Universitätsklinikum Aachen · DEInstitutul National Victor Babes · RORWTH Aachen University · DEUniversity of Medicine and Pharmacy of Craiova · RO

Funding

Faculty of Medicine of the RWTH Aachen University Clinician Scientist programInterdisciplinary Centre for Clinical Research IZKF Aachen junior research group to E.A.L
6 · The paper itself

Abstract

Myocardial infarction remains the most common cause of heart failure with adverse remodeling. MicroRNA (miR)155 is upregulated following myocardial infarction and represents a relevant regulatory factor for cardiac remodeling by engagement in cardiac inflammation, fibrosis and cardiomyocyte hypertrophy. Here, we investigated the role of miR155 in cardiac remodeling and dysfunction following myocardial infarction in a dyslipidemic mouse model. Myocardial infarction was induced in dyslipidemic apolipoprotein E-deficient (ApoE

Indexed as

AnimalsDisease Models, AnimalEchocardiographyFibrosisHeart FailureHeart VentriclesMaleMiceMice, Inbred C57BLMice, KnockoutMicroRNAsMyocardial InfarctionMyocardiumMyofibroblastsStroke VolumeVentricular Function, LeftMicroRNAsMirn155 microRNA, mousecardiovascular diseasedyslipidemiaheart failuremicroRNAmyocardial infarction

Identifiers

PMID34067440
PMCPMC8197013
OpenAlexW3165689186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.