Evidence map›Paper›PMID 34067439›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis and Modeling of Ezetimibe Analogues.

Mateo M Salgado, Alejandro Manchado, Carlos T Nieto, David Díez, Narciso M Garrido

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mateo M SalgadoDepartamento de Química Orgánica, Universidad de Salamanca, 37008 Salamanca, Spain.ORCID 0000-0001-9203-175X
Alejandro ManchadoDepartamento de Química Orgánica, Universidad de Salamanca, 37008 Salamanca, Spain.
Carlos T NietoDepartamento de Química Orgánica, Universidad de Salamanca, 37008 Salamanca, Spain.
David DíezDepartamento de Química Orgánica, Universidad de Salamanca, 37008 Salamanca, Spain.ORCID 0000-0002-7261-8454
Narciso M GarridoDepartamento de Química Orgánica, Universidad de Salamanca, 37008 Salamanca, Spain.ORCID 0000-0002-1704-8073
Universidad de Salamanca · ES

Funding

Junta de Castilla y León SA076P20, UIC021
6 · The paper itself

Abstract

Ezetimibe is a well-known drug that lowers blood cholesterol levels by reducing its absorption in the small intestine when joining to Niemann-Pick C1-like protein (NPC1L1). A ligand-based study on ezetimibe analogues is reported, together with one-hit synthesis, highlighted in the study. A convenient asymmetric synthesis of (2

Indexed as

Chemistry Techniques, SyntheticDrug DesignAllelesAmidesAmino AcidsAnticholesteremic AgentsCholesterolEzetimibeHumansLigandsMagnetic Resonance SpectroscopyMembrane Transport ProteinsMolecular Docking SimulationPyridinesStereoisomerismAmidesAmino AcidsAnticholesteremic AgentsCholesterolEzetimibeLigandsMembrane Transport ProteinsNPC1L1 protein, humanPyridinesBaylis–Hillmanchiral amide additioncholesteroldomino reactionezetimibeligand studypharmacophoreβ-lactam

Identifiers

PMID34067439
PMCPMC8196997
OpenAlexW3164487279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.