Evidence map›Paper›PMID 34067399›Full record

ArticleMolecules (Basel, Switzerland)2021

Facile One-Pot Multicomponent Synthesis of Pyrazolo-Thiazole Substituted Pyridines with Potential Anti-Proliferative Activity: Synthesis, In Vitro and In Silico Studies.

Islam H El Azab, Rania B Bakr, Nadia A A Elkanzi

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Development of Novel Class of Phenylpyrazolo[3,4-International journal of molecular sciences · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Islam H El AzabFood Science and Nutrition Department, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-1548-1102
Rania B BakrDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.ORCID 0000-0001-6564-1712
Nadia A A ElkanziChemistry Department, College of Science, Jouf University, P.O. Box 2014, Sakaka, Saudi Arabia.

Funding

Taif University TURSP-2020/27
6 · The paper itself

Abstract

Pyrazolothiazole-substituted pyridine conjugates are an important class of heterocyclic compounds with an extensive variety of potential applications in the medicinal and pharmacological arenas. Therefore, herein, we describe an efficient and facile approach for the synthesis of novel pyrazolo-thiazolo-pyridine conjugate

Indexed as

Drug Screening Assays, AntitumorAntineoplastic AgentsCell Line, TumorChemistry Techniques, SyntheticComputer SimulationDNA Topoisomerases, Type IIEtoposideHeLa CellsHumansInhibitory Concentration 50Magnetic Resonance SpectroscopyMass SpectrometryMolecular Docking SimulationPC-3 CellsPyrazolesPyridinesAntineoplastic AgentsDNA Topoisomerases, Type IIEtoposidePyrazolesPyridinesThiazolesanticancer activitymolecular dockingmulticomponent condensationN-Heterocyclespyranpyrazole-3-carbothioamidepyridinethiazole

Identifiers

PMID34067399
PMCPMC8196987

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.